Study on arsenic toleranc induced by bone marrow mesenchymal stem cells

  Objective   To obtain stable arsenic tolerance in bone marrow mesenchymal stem cells(MSCs).

  Methods   Bone marrow mesenchymal stem cells were exposed atlow level arsenite.The cell surviral rate and LC₅₀ were measured by MTT.The resistance to arsenite was observed.

  Results   Bone mar rowmesenchymal stem cells exposed to 1mol/L sodium arsenite for 18 weeks exhibited dramatic resistance to acute arsenite toxicity.The LC₅₀ for acute arsenite exposure in these chronic arsenic-esposed cells was 25.8mol/L versus 11.4mol/L in control cells.

  Conclusion   Acquisition of stable arsenic toler ance in bone mar row mesenchmal stem cells was available.