Experin ental Study on the Effects of BSO and NAC on Cadmium Toxisity in Syrian Hansters

Syrian ham stars w ere given subcutaneous injections of cadmium chloride in different dose and 24 hours later serum LDH and GPT urinary LDH activities and protein contents Cd and GSH concentrations in the liver and renal cortex were detenn inecl T he results show ed that serum LDH adn GPT activite Cd con centations in the liver and renal cortex and GSH onscentraion in the rena lcortex in the higher dose C-treated group w ere increased significantly It was indicated that acute Cd administratpn inducecl liver damage in haln sters Animals were also pretreated w ith BSO or NAC before Cd adn inistration It w as found that BSO enhancecl Cd-induced hepatic and renal toxicity andNAC offsetCd-induc;edhepatic toxicity enhanc;ed Cd一nduc;ed renal toxicity The mechanin m ay be BSOor NAC pretreatrnent causing the changes of intracellular GSH level.