Observation on Effects of Secondary Immune with Bivalent Inactivated HFRS Vaccine for Volunteers Previously Immunized with HNT Type HFRS Vaccine

Objective Observation on effects of secondary Immune with bivalent inactivated HFRS vaccine in volunteers previously immunized with HNT tpe HFRS vaccine.Methods 7 volunteers Previously Immunized with three injections in 1988 and an additional injection in 1989 of HNT univalent HFRS vaccine were inoculated with one injection of bivalent(HNT + SEO type)inactivated HFRS vaccine in 1997.The sera collected in 14 day after the immunization were analyzed for HNT and SEO type antibody titers respectively by the method of PRNT.Results The neutral antibodies to both HTN and SEO can be successfully detected in volunteers.Compared to the titers of antibody to HNT.the SEO type antibody titers appeared to be kink of lower which however can also fully meet the requirements for protection the attacking of SEO Hantavirus.Conclusion The secondary immune with bivalent HFRS vaccine was a very important measure to effectively prevent the infection of both HNT and SEO Hantavirus.