Objective  To construct an evaluation framework for prioritizing the inclusion of non-program vaccines into planned immunization of Shenzhen city.

  Methods  After developing a preliminary evaluation framework with literature studies, we conducted two rounds of Delphi consultation among 15 experts for screening relevant indicators and modifying the framework during March – July 2022. The weight of each indicator in the framework was calculated using analytic hierarchy process.

  Results  The active coefficients for the two rounds of expert consultation were 100% and 86.67% and the expert authority index was 0.84 for the two rounds of consultation. The concordance coefficients for the experts′ comprehensive evaluation scores of all indicators ranged between 0.199 – 0.465 (P < 0.05) and 0.253 – 0.442 (P < 0.05) in the first and second consultation. Totally 4 primary, 13 secondary and 34 tertiary indicators were included in the finally established evaluation framework for assessing the priority of a non-program vaccine to be included into planned immunization on 4 dimensions: disease impact (disease burden, economic burden, prevention urgency), vaccine effect (safety, efficacy, related attributes), vaccination feasibility (policy making, fund, vaccine supply, human resource, surveillance), and cost-effectiveness (economic and social benefit). The combined weights were between 0.003 and 0.279 for all the indicators.

  Conclusion  The established evaluation framework is innovative and reliable and could provide a reference tool in selecting a vaccine to be included into Shenzhen municipal immunization program.