Abstract: Pregnant women are a high-risk group for several infectious diseases. Vaccination is the most economical and effective way to prevent infectious diseases in the general population, but for pregnant women, vaccination can present both risks and benefits. On one hand, vaccinated during pregnancy may protect the pregnant woman, fetus, and newborn from harm from vaccine-preventable diseases; on the other hand, it may also increase the risk of adverse events. Therefore, conducting safety assessments of vaccination during pregnancy not only provides evidence-based support for developing immunization program strategies but is also critical for ensuring maternal and infant health and preventing maternal and infant adverse events caused by vaccination. This article classifies relevant vaccines according to the principles of immunization during pregnancy in various guidelines and reviews national and international research on the safety of immunization during pregnancy. By comprehensively understanding the current status of research on the safety of immunization during pregnancy, it provides a reliable basis for improving China′s immunization strategies.