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中国妊娠期妇女戊型肝炎病毒IgG抗体阳性率meta分析

Positive rates of hepatitis E virus IgG antibodies in pregnant women in China: a meta-analysis

    摘要
  • 摘要:
    目的 了解中国妊娠期妇女戊型肝炎病毒（HEV）免疫球蛋白G（IgG）抗体的阳性率，为我国妊娠期妇女戊型肝炎的预防控制提供参考依据。
    方法 检索Pubmed、Web of Science、中国知网和万方资源数据库，并辅以文献追溯法收集1989年1月1日—2023年12月31日国内外公开发表的中国妊娠期妇女HEV血清流行率调查的相关文献；应用R 3.5.2软件对纳入的文献进行meta分析。
    结果 最终纳入15篇文献（中文文献8篇、英文文献7篇），累计研究对象36 188人；meta分析结果显示，中国妊娠期妇女HEV IgG抗体阳性率为13%（95%CI=11%～16%）；亚组分析结果显示，年龄<30岁和≥30岁妊娠期妇女的HEV IgG抗体阳性率分别为18%（95%CI=12%～24%）和15%（95%CI=10%～19%），居住在城市和农村地区妊娠期妇女的HEV IgG抗体阳性率分别为29%（95%CI=3%～55%）和25%（95%CI=5%～45%），孕早期、孕中期和孕晚期妊娠期妇女的HEV IgG抗体阳性率分别为16%（95%CI=3%～28%）、13%（95%CI=7%～18%）和15%（95%CI=10%～21%），不同年龄、居住地和孕期妊娠期妇女HEV IgG抗体阳性率差异均无统计学意义（均P>0.05）；敏感性分析和发表偏倚检验结果显示，本次meta分析纳入的文献不存在发表偏倚，结果较为稳定。
    结论 中国妊娠期妇女HEV IgG抗体阳性率较高，应重点关注妊娠期妇女这一高危人群，做好HEV感染的防控工作。

     

    Abstract:
    Objective To investigate the positive rate of hepatitis E virus (HEV) immunoglobulin G (IgG) antibodies in pregnant women in China and to provide a reference for the prevention and control of hepatitis E in the women.
    Methods PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang Data were searched, supplemented by a retrospective literature search, to collect relevant literature published domestically and internationally from January 1, 1989, to December 31, 2023, on the seroprevalence of HEV in pregnant women in China. R 3.5.2 software was used for meta-analysis of the included literature.
    Results A total of 15 articles (8 in Chinese and 7 in English) were included, with a cumulative study population of 36 188. The meta-analysis showed that the positive rate of HEV IgG antibodies among pregnant women in China was 13% (95% confidence interval 95%CI: 11%–16%). Subgroup analysis showed that the positive rates of HEV IgG antibodies in pregnant women younger than 30 years old and 30 years old and older were 18% (95%CI: 12%–24%) and 15% (95%CI: 10%–19%), respectively; the positive rates of HEV IgG antibodies in pregnant women living in urban and rural areas were 29% (95%CI: 3%–55%) and 25% (95%CI: 5%–45%), respectively; and the positive rates of HEV IgG antibodies in pregnant women in the first, second, and third trimesters were 16% (95%CI: 3%–28%), 13% (95%CI: 7%–18%), and 15% (95%CI: 10%–21%), respectively. There were no statistically significant differences in the positive rates of HEV IgG antibodies among pregnant women of different ages, residences, and gestational ages (all P>0.05). Sensitivity analysis and publication bias tests showed that there was no publication bias in the literature included in this meta-analysis, and the results were relatively stable.
    Conclusions The positive rate of HEV IgG antibodies among pregnant women in China is relatively high. Attention should be paid to this high-risk group, and prevention and control measures for HEV infection should be strengthened.

     

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