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食源性黄曲霉毒素疾病负担研究进展

A review of research progress on disease burden of foodborne aflatoxins

  • 摘要: 黄曲霉毒素(AF)是一类真菌次级代谢产物,可污染多种农作物及衍生产品,是全球食品安全的重大挑战。国际癌症研究机构(IARC)将AFB1、AFB2、AFG1和AFG2列为1类致癌物,主要导致人类肝细胞癌(HCC),也可影响儿童的生长发育和损害人体免疫系统等,对人群产生不同程度的健康负担。世界卫生组织在2015年发布了全球食源性AF疾病负担,也有多个国家和地区开展了人群食源性AF疾病负担研究。本文对2010 — 2023年的食源性AF疾病负担研究进展进行了综述,为未来开展更全面的疾病负担研究提供依据。

     

    Abstract: Aflatoxins (AFs) are fungal secondary metabolites that can contaminate various agricultural crops and their derived products, posing a significant global food safety challenge. The International Agency for Research on Cancer (IARC) has classified AFB1, AFB2, AFG1 and AFG2 as Group 1 carcinogens, primarily causing hepatocellular carcinoma (HCC) in humans, but also affecting growth and development in children and damaging the human immune system, resulting in varying degrees of health burden to populations. The World Health Organization published the global burden of foodborne AF in 2015, and several countries and regions have conducted population-based studies on the burden of foodborne AF. This article reviews the progress of foodborne AF disease burden research from 2010 to 2023, providing a foundation for more comprehensive disease burden studies in the future.

     

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