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艾滋病免疫重建不良影响因素研究进展

Research progress on factors influencing suboptimal immune reconstitution in HIV infection: a systematic literature review

  • 摘要: 艾滋病即获得性免疫缺陷综合征 (AIDS) ,是一种由人类免疫缺陷病毒(HIV)感染引起的免疫缺陷综合征。目前临床上采用的抗逆转录病毒治疗(ART) 是治疗和管理HIV感染的主要方法。随着ART的普及, HIV病毒得到抑制,机体免疫功能逐渐恢复,HIV相关疾病的发病率和死亡率显著降低,但仍有部分患者即使经过长期、规律、有效的ART 治疗,HIV病毒得到了有效抑制,其免疫功能仍未能恢复至正常状态,这一现象被称为免疫重建不良(INR)。迄今为止,在HIV感染的患者中,免疫重建不良的潜在机制尚未完全阐明,但研究表明多种因素可能与其有关。本文通过广泛梳理文献,对 INR的影响因素进行综述,为改善 HIV/AIDS 患者的免疫重建不良提供临床参考。

     

    Abstract: Acquired immunodeficiency syndrome (AIDS) is an immunodeficiency syndrome caused by infection with the human immunodeficiency virus (HIV). Currently, antiretroviral therapy (ART) is the primary method for treating and managing HIV infection. With the widespread use of ART, the HIV virus is suppressed, the body′s immune function gradually recovers, and the morbidity and mortality of HIV-related diseases are significantly reduced. However, some patients still fail to restore their immune function to a normal state even after long-term, regular, and effective ART, a phenomenon known as immune non-response (INR). To date, the underlying mechanisms of INR in HIV-infected patients have not been fully elucidated, but studies have shown that multiple factors may be involved. This article reviews the influencing factors of INR through an extensive literature review to provide clinical references for improving INR in HIV/AIDS patients.

     

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