Abstract: The White House unveiled the inaugural "U.S. Government Global Health Security Strategy (GGHS)" in 2019, followed by an updated version in April 2024. The revised strategy outlines a new strategic vision, approach, objectives, and implementation mechanisms. It emphasizes strategic transformation through expanding interdepartmental collaboration, securing diversified funding sources, mobilizing societal and civic participation, and pursuing leadership in international rule-making. These initiatives aim to enhance capabilities for preventing and responding to health security risks while safeguarding both domestic and global health security interests of the United States. This article examines the core framework of the updated strategy and contrasts the similarities and differences between the previous and current strategies, offering referenceable insights for China′s implementation of the Global Security Initiative and its efforts to promote the rule of law in global health security.