Abstract: Amid accelerating globalization, compounded by climate change and shifting international dynamics, biosafety risks have become increasingly complex. In the public health domain, these risks manifest in both laboratory and field settings. While laboratory biosafety systems are well-established, field biosafety remains understudied globally due to the inherent complexity and challenges of risk management in uncontrolled environments. This study systematically reviews current progress in field biosafety research, integrating international guidelines and case studies to highlight the critical importance of effective risk mitigation. The findings aim to inform policy and strengthen national biosafety frameworks, offering valuable insights for enhancing prevention, control, and governance systems.