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2025年河南省一起肺炭疽疫情调查

Epidemiological investigation of a pulmonary anthrax case in Henan province, 2025

  • 摘要:
    目的 分析河南省一起肺炭疽疫情的感染来源和流行病学特征,为肺炭疽的防控提供科学依据。
    方法 对河南省2025年1月报告的一起肺炭疽疫情进行现场流行病学调查及相关处置工作,同时采集病例及环境样本进行实验室检测。
    结果 河南省此次疫情共报告肺炭疽病例1例,职业为农民,因参与宰杀羊只或在活羊交易市场活动中感染;早期症状为发热,后表现为突发气喘、呼吸困难、胸闷、头晕头痛和恶心等症状,肺组织和肺泡灌洗液经高通量基因测序均检出炭疽芽孢杆菌序列,炭疽杆菌核酸检测均为阳性,血清标本炭疽杆菌免疫球蛋白G(IgG)抗体阳性。病例经治疗后痊愈出院,密切接触者及风险人员均未出现相关临床症状,相关环境样本炭疽杆菌核酸检测结果均为阴性。
    结论 河南省此次疫情为一起通过吸入感染的原发性肺炭疽偶发疫情,仅涉及1例病例,未发生续发病例;病例感染来源于羊,感染途径可能与宰杀或者在活羊交易市场活动有关。

     

    Abstract:
    Objective To analyze the source of infection and epidemiological characteristics of a pulmonary anthrax case in Henan province, thus providing a scientific basis for the prevention and control of pulmonary anthrax.
    Methods A pulmonary anthrax case reported in Henan province in January 2025 was investigated on site, with standard control measures implemented. Samples were collected from the patient and the environment for laboratory testing.
    Results In this outbreak in Henan province, one case of pulmonary anthrax was reported. The patient, whose occupation was a farmer, was infected due to participating in sheep slaughtering or activities in a live sheep trading market. The early symptom was fever, followed by sudden asthma, difficulty in breathing, chest tightness, dizziness, headache, nausea and other symptoms. High-throughput gene sequencing of the lung tissue and alveolar lavage fluid both detected sequences of Bacillus anthracis, and the nucleic acid test for B. anthracis was positive. The serum sample tested positive for B. anthracis IgG antibody. The patient was cured and discharged after treatment. No relevant symptoms appeared in close contacts or at-risk personnel, and the nucleic acid test results for B. anthracis in relevant environmental samples were all negative.
    Conclusions This outbreak in Henan province is an incidental case of pulmonary anthrax caused by inhalation. The source of infection is sheep, with potential routes of infection involving slaughtering activities or exposure at the live sheep market.

     

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