高级检索

潍坊市农村居民碳青霉烯耐药肠杆菌科细菌肠道定植情况及相关因素：一项横断面调查

Intestinal colonization of carbapenem-resistant Enterobacteriaceae and associated factors in rural residents in Weifang: a cross-sectional survey

    摘要
  • 摘要:
    目的  了解山东省潍坊市农村居民碳青霉烯耐药肠杆菌科细菌（CRE）肠道定植情况及其相关因素，为基层社区耐药菌的防控提供依据。
    方法  于2023年11月采用多阶段分层随机抽样方法在潍坊市抽取12个村的833名农村居民进行问卷调查和粪便样本CRE检测，分析CRE肠道定植情况及相关因素。
    结果 潍坊市最终纳入分析的767名农村居民中，粪便样本检测出CRE者59人，CRE肠道定植率为7.69%；检出的59份CRE菌株样本中，大肠埃希菌38份（64.41%），人型埃希氏菌5份（8.47%），霍氏肠杆菌5份（8.47%），肺炎克雷伯氏菌4份（6.78%），奇异变形杆菌4份（6.78%），弗氏柠檬酸杆菌2份（3.39%），变栖克雷伯菌1份（1.69%）；多因素非条件logistic回归分析结果显示，饮用未煮沸的井水/自来水（OR=3.36，95%CI=1.16～9.71）和使用动物粪便施肥（OR=2.10，95%CI=1.05～4.24）潍坊市农村居民的CRE肠道定植率较高，如厕后洗手（OR=0.32，95%CI=0.15～0.70）和使用室内厕所（OR=0.18，95%CI=0.05～0.73）潍坊市农村居民的CRE肠道定植率较低。
    结论 山东省潍坊市农村居民CRE肠道定植率处于较高水平，主要菌种为大肠埃希菌，饮用未煮沸的井水或自来水、使用动物粪便施肥、如厕后洗手和使用室内厕所与当地农村居民CRE定植显著相关。

     

    Abstract:
    Objective To investigate the intestinal colonization rate of carbapenem-resistant Enterobacteriaceae (CRE) among rural residents in Weifang city, Shandong province and identify the associated factors, thereby providing evidence for the prevention and control of drug-resistant bacteria at the community level.
    Methods In November 2023, a multi-stage stratified random sampling method was employed to select 833 rural residents from 12 villages in Weifang city, Shandong province. Questionnaire surveys and fecal sample CRE detection were conducted. The colonization rate of CRE in the intestine and the associated factors were analyzed.
    Results Among the 767 rural residents ultimately included in the analysis, 59 individuals had fecal samples that tested positive for CRE, resulting in an intestinal colonization rate of CRE being 7.69%. Among the 59 samples that tested positive for CRE strains, 38, 5, 5, 4, 4, 2, and 1 samples were positive for Escherichia coli (64.41%), Escherichia albertii (8.47%), Enterobacter hormaechei (8.47%), Klebsiella pneumoniae (6.78%), Proteus mirabilis (6.78%), Citrobacter freundii (3.39%), and Klebsiella variicola (1.69%), respectively. Multivariate unconditional logistic regression analysis revealed that drinking unboiled well water or tap water (OR = 3.36, 95%CI: 1.16–9.71) and using animal manure as fertilizer (OR = 2.10, 95%CI: 1.05–4.24) were positively correlated with the intestinal colonization rate of CRE among rural residents in Weifang city. In contrast, handwashing after using the toilet (OR = 0.32, 95%CI: 0.15–0.70) and using an indoor toilet (OR = 0.18, 95%CI: 0.05–0.73) were negatively correlated with the intestinal colonization rate.
    Conclusions The intestinal colonization rate of CRE is high among rural residents in Weifang city, Shandong province, with E. coli being the predominant species. Drinking unboiled well water or tap water, using animal manure as fertilizer, handwashing habits after using the toilet, and using an indoor toilet are significantly associated with CRE colonization in the local rural population.

     

    • HTML全文
    • 参考文献(35)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回