Abstract: To evaluate the applying value of BP network in disease prediction,to give clues for population prevention of prostate cancer.The prevalence of prostate cancer of WuHan residents(male)was predicted using BP network.Using the data of the year 1990～ 1995 to predict the prevalence of prostate in 1996～1997,the results showed that:as the incidence of the prostate cancer,the fitting average error was 3.83%,R² is 0.7734,and the predicting average error was 5.15%.As the mortality rate of the prostate cancer,the fitting average error was 4189%,R² was 019515,and the predicting average error is 2.51%.Using the data of the year 1990～1997 to predict the prevalence rate of 1998～2000,the results showed that:As the incidence of the prostate cancer,the fitting average error was 3124%,R² was 018195.As the mortality rate of the prostate cancer,the fitting average error was 4.02%,R² was 019554.The predicting results showed that:in the next few years,the incidence of prostate cancer will be a relatively steady state and the mortality rate of prostate cancer will show a slowly rising trend.