蒙族高血压患者ACE基因多态性与胰岛素抵抗

Association between angiotension-converting enzyme gene polymorphism and insulin resistance in Mongolian hypertensives

摘要:
目的探讨蒙古族高血压人群血管紧张素转换酶(ACE)基因Ⅰ/D多态性与胰岛素抵抗及血脂的关系。
方法选择115例高血压者和114例血压正常者检测血脂、血糖和胰岛素水平; 分析高血压组ACE基因Ⅰ/D多态性与胰岛素抵抗及血脂的关系。
结果在高血压组及正常对照组中, 未发现ACE基因Ⅰ/D多态性胰岛素抵抗及血脂有关联(P > 0.05)。
结论蒙古族高血压人群中ACE基因Ⅰ/D多态性与胰岛素抵抗及血脂水平无关联。

Abstract:
Objective To explore the association between angiotensin-converting enzyme(ACE)gene Ⅰ/D polymorphism and insulin resistance and blood lipid in Mongolian hypertensives.
Methods 115 Mongolian hypertensives and 114 Mongolian normotensives were selected to test blood lipid, blood glucose and insulin; analyzing examining the insertion/deletion polymorphism of ACE gene in hypertensives and normotensives.
Results These was no significant difference to be found between ACE gene Ⅰ/D polymorphism and insulin resistance and blood lipid in Mongolian hypertensives and normotensives(P > 0.05).
Conclusion The ACE gene polymorphism was not related to insulin resistance and blood lipid in Mongolian hypertensives.