Abstract: Objective To evaluate the relationship between G protein-coupled receptors 37 and child autism.Methods From January 2013 to November 2013,120 child autism outpatients and 120 healthy children were recruited from a hospital in Shenyang city. Children autistic disorder was investigated based on a questionnaire survey and the level of G protein-coupled receptors 37 was detected using enzyme-linked immunosorbent assay.Results The level of G protein-coupled receptors 37 in childhood autism group(12.27±1.73)was significantly higher than that in healthy group(5.35±1.66,t=31.61,P<0.001). There was a positive correlation between G protein-coupled receptors 37 and childhood autism(r=0.87,P<0.001).Conclusion G protein-coupled receptors 37 may influence the development of children autistic disorder,and it may be an indicator for children autistic disorder.