5-羟色胺受体相关基因与自杀行为相关性

邱晓惠; 马靖松; 宋珺瑶; 王琳; 杨秀贤; 乔正学; 杨艳杰

doi:10.11847/zgggws2015-31-09-12

5-羟色胺受体相关基因与自杀行为相关性

doi: 10.11847/zgggws2015-31-09-12

哈尔滨医科大学医学心理教研室, 黑龙江哈尔滨 150081

基金项目:

国家自然科学基金(81102175)

详细信息

作者简介:
邱晓惠(1977-),女,黑龙江哈尔滨人,副教授,博士,研究方向:情绪障碍的遗传及神经心理。

通讯作者:
杨艳杰,E-mail:yanjie1965@163.com

中图分类号: C913.9;Q421
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出版历程
- 接收日期: 2014-04-17
- 刊出日期: 2015-09-10

Association between serotonin receptor genes and suicide behavior

Department of Psychology, Heilongjiang Medical University, Harbin, Heilongjiang Province 150081, China

摘要

摘要: 目的探讨自杀行为与5-HT1BR基因rs6298,5-HT2AR基因rs6311、rs6313及5-HT2BR基因rs765458单核苷酸多态性的关联。方法提取中国北方地区281例伴有冲动性自杀行为的抑郁症患者(病例组)和300名健康对照者(对照组)基因组DNA,采用TapMan探针单核苷酸多态性(SNP)基因分型技术检测病例组及对照组所选位点基因型;统计分析采用χ²检验比较病例组和对照组的基因型和等位基因的分布差异。结果病例组和对照组的5-HT2AR基因rs6311(χ²=20.736,P=0.000)、rs6313(χ²=7.645,P=0.022)基因型频率差异有统计学意义,5-HT1BR基因rs6298、5-HT2BR基因rs765458基因型组差异无统计学意义(P>0.05),5-HT1BR基因rs6298,5-HT2AR基因rs6311、rs6313及5-HT2BR基因rs765458组等位基因频率差异无统计学意义(P>0.05)。结论5-HT2AR基因rs6311、rs6313位点SNP与自杀行为有明显关联,5-HT1BR基因rs6298、5-HT2BR基因rs765458位点SNP与自杀行为无明显关联。
- 自杀 /
- 5-羟色胺(5-HT) /
- 基因型
Abstract: ObjectiveTo explore the associations of single nucleotide polymorphism(SNP) of 5-hydroxytryptamine-1B receptor(5-HT1BR) gene rs6298,5-hydroxytryptamine 2A receptor(5-HT2AR) gene rs6311 and rs6313,and 5-hydroxytryptamine 2B receptor(5HT2BR) gene rs765458 with suicidal behavior.MethodsThe blood samples of 281 depression patients with impulsive suicide attempt and 300 age-matched healthy physical examinees were selected in a hospital from November 2012 through March 2014.The DNA of the blood samples was extracted and genoptyped with TapMan SNP genotyping probe.χ² test was adopted in statistical analyses to compare the differences in the distribution of gene alleles between the cases and controls.ResultsThere were significant differences in the genotype frequencies of 5-HT2AR gene rs6311(χ²=20.736,P=0.000) and rs6313(χ²=7.645,P=0.022) between the cases and the controls.No significant differences were observed in genotypes of 5-HT1BR gene rs62985 and 5-HT2BR gene rs765458 and in the allele frequencies of 5-HT1BR gene rs6298,5-HT2AR gene rs6311 and rs6313,and 5-HT2BR gene rs765458 between the cases and the controls(all P>0.05).ConclusionThe SNPs of 5-HT2AR gene rs6311 and rs6313 are significantly associated with suicidal behavior,but the SNPs of 5-HT1BR gene rs6298,5-HT2BR gene rs765458 have no significant association with suicidal behavior.
- suicide /
- 5-HT /
- gene type

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