Abstract: Objective To take the closed crowd(Keriya population)living in the downriver area of Kerian in the hinterland of Takala Makan desert as the research object to investigate rule of distr action of the gene polymor phism of beta globin A vall loci.Methods Use polymerase restrictive fragment length polymorphism technique and the imagery analysis method to carry on the examination of chromosomes of fifty-four Keriy a individuals without blood relationships from each others.Also to apply the SPSS 12.0 statistics software to analyze gene frequency,the gene frequency distribution,and carry on the comparison with other races.Results The allele gene frequency of beta globin Avallloci in Kriy a crowds.Beta-Gg1/2=48.15%,beta-Gg1/1=18.52%,beta-Gg2/2=33.33%.These three kind of genes distribution conformed to HardyWeinberg law.Compared with the foreign crowd,beta the-Gg1/1 distribution frequency remarkably ishigher than South Korean and the Cambodian crowd(χ²=7.154 3,χ²=6.102 4,P=0.005),but the Gg2/2 distr ibution frequency remar kably was lower than south China the Han Nationality crowd(χ²=6.216 3,P=0.01).Beta-Gg^* 1 and beta the-G^*g2 allele frequency analysis demonstrated that the Keriya closed crowd had remarkable difference from the Han nationality of south China and the Japanese crowd(χ²=10.9351,P=0.001).But compard with other crowds,there was not remarkable difference(P>0.05).Conclusion A velle gene in health Keria closed crowd distributed with characteristic,and has provided Keriya crowd beta-globin A vaII position spot allele frequency distribution material,which can provid the important reference data for genetics and disease relevant research.