甘草对小鼠雄性生殖细胞遗传损伤的防护作用

Preventive effect of Glycyrrhiza uralensis fisch on damage of genetic materials in male mouse reproductive cells

摘要:
目的观察中草药甘草对醋酸铅引起的小鼠雄性生殖细胞遗传损伤的防护作用。
方法采用小鼠精子畸形试验、精原细胞染色体畸变试验和小鼠精子非程序DNA合成(UDS)试验。
结果在一定剂量范围内, 甘草对醋酸铅所诱发的小鼠精子畸形、精原细胞染色体畸变和小鼠精子非程序DNA合成有明显的抑制作用(P < 0.01)。
结论甘草对小鼠雄性生殖细胞遗传损伤具有防护作用。

Abstract:
Objective To observe the preventive effect of Glycyrehize uralensis fisch on damage of genetic M aterials in male mouse reproductive cells induced by Pb(CH_3MCOO)₂.
Methods Sperm abnormality test, Chromosome aberration of spermatogonia and unscheduled DNA synthesis(UDS)test in male mouse reproductive cells were used in the study.
Results Glycyrrhiza uralensis fisch inhibited significantly sperm abnormality, chromosome aberration of spermatogonia an UDS in mouse reproductive cells induced by Pb (CH₃COO)₂(P < 0.01).
Conclusion Glycyrrhiza uralensis fisch shows a protective effect, namely antimutagenesis, on injury of genetic materials in reproductive cells of male mouse.