硒对氟致大鼠脂质过氧化拮抗作用

Antagonistic effects of selenium on fluoride-induced lipid peroxide in rats

摘要:
目的研究氟与脂质过氧化的关系, 硒对氟引起的脂质过氧化的影响.
方法将40只SD大鼠随机分为4组, 按对照、氟、硒、硒氟不同饮水饲养8周, 观察硒对氟引起大鼠血清、肝、肾、心、睾丸脂质过氧化的影响.
结果与对照组相比, 加氟组全血谷胱甘肽过氧化物酶(GSH-Px)显著下降, 血清、肝、肾、心、睾丸的脂质过氧化(LPO)含量水平明显升高; 加硒组增强机体抗氧化功能, 提高全血GSH-Px活性, 降低机体LPO含量.
结论可通过补硒来拮抗氟引起的脂质过氧化.

Abstract:
Objective To study the relation between fluorine and lipid peroxide, and the effects of selenium of fluor ideinduced lipid peroxide.
Methods 40 rats were divided into four groups(control, fluorine, selenium, Se-fluorine by drinking) in random and fed for eight weeks.To observe the effects of selenium of fluoride-induced lipid peroxide in blood serum, liver, kidney, heart, testis in rats.
Results the glutathione peroxidase(GSH-Px)in whole blood of the fluorine group was significant decrease, and the obvious increase of lipid peroxide(LPO)levels in blood serum, liver, kidney, heart, testis can be observed.Adding the selnium in drinking can increase the power of anti-oxidation, as well as increase the activities of GSH-Px and decrease the levels of LPO.
Conclusion Selenium can antagon fluoride-induced lipid peroxide.