Abstract: Objective To evaluate the associations of gene polymorphisms in adipocytokines tumor necrosis factor α（ TNFα）,leptin receptor and adiponectin with type 2 diabetes mellitus（ T2DM） using method of meta-analysis. Methods Hardy-Weinberg equilibrium（ HWE） test was used to check genetic equilibrium between genotypes for the selected literature. A fixed or random effect model was used on the basis of heterogeneity. Publication bias was quantified and examined with the Begg’s and Egger’s method. The meta-analysis was performed with Review Manager 5. 1 Software. Results Fifty reports met the inclusion criteria for this meta-analysis. No significant publication bias was identified in the selected literature. There were no statistical significant results found regarding the association of leptin receptor（ LEPR） single nucleotide polymorphism（ SNP）-668A ＞ G and T2DM. However,for TNFα SNP-308G ＞ A,the odds ratioORand 95%confidence interval 95% CIfor A vs G allele and GA + AA vs GG were 1. 38（ 1. 11- 1. 71） and 1. 26（ 1. 05- 1. 51）,respectively,with statistical significances. For adiponectin SNP + 45T ＞ G,the OR（ 95% CI） for G vs T allele and GG +TG vs TT was 1. 17（ 1. 03- 1. 33） and 1. 16（ 1. 01- 1. 34）. Conclusion There is no significant association between the LEPR SNP-668A ＞ G polymorphisms and risk for T2DM. However,TNFα SNP-308G ＞ A and adiponectin SNP + 45T ＞G might be risk factors for type 2 diabetes mellitus.