Abstract: Objective To evaluate the quality of life（ QOL） in patients with chronic hepatitis B and to explore its influencing factors. Methods Cluster random sampling was taken and the Medical Outcomes Study 36-Iterm Short Form Health Survey（ SF-36） was used among 342 chronic hepatitis B patients. The data collected were analyzed by using ordinal logistic regression analysis. Results Compared with the domestic norm,the scores of general health（ 50. 41 ± 19. 70）,physical functioning（ 69. 74 ± 35. 06）,role-physical（ 32. 41 ± 44. 81）,role-emotional（ 64. 25 ± 46. 31）,social functioning（ 78. 71 ± 24. 37）,bodily pain（ 73. 03 ± 23. 50）,vitality（ 55. 60 ± 17. 90）,and mental health（ 64. 65 ± 17. 20） were lower（ P ＜ 0. 001 for all） among the patients. Results of ordinal logistic regression analysis showed that age,chronic diseases,and hospitalization had negative influence on QOL,but higher per capita income had positive influence（ P ＜0. 05）. Conclusion The patients with chronic hepatitis B had poorer QOL than general population and the QOL of the patients was influenced by a number of factors.