Analysis of drug resistance surveillance of tuberculosis in Fujian province
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摘要: 目的 通过开展福建省结核病耐药监测点监测,了解结核病耐药状况,为制订结核病控制对策提供依据。方法 对福建省9个设区市的9个监测点2008年9月-2009年8月门诊新登记涂阳患者分离的结核分枝杆菌复合群,采用WHO/IUATLD推荐的比例法进行异烟肼、链霉素、利福平和乙胺丁醇耐药性检测。结果 共1 014例病例纳入监测分析,总体耐药率为19.8%,耐多药率为4.6%,其中初始耐药率为17.9%,初始耐多药率为3.4%,获得性耐药率为44.0%,获得性耐多药率为20.0%。结论 福建省结核病耐药监测点耐药率低于全国平均水平,但高于国际平均水平,今后仍要进一步加强耐药结核病的防治工作。Abstract: Objective To access the situation of drug-resistance tuberculosis in Fujian province and to provide evidence for making TB control policy.Methods All new registered sputum smear-positive patients in 9 surveillance sites of Fujian province were collected from September 2008 to August 2009.Identification and susceptibility tests were done for all culture positive samples.Proportion method was used to conduct drug sensitivity test of isonizid,rifampicin,streptomycin,and ethambutol according to the guidelines for surveillance of drug resistance(DR) in tuberculosis of WHO/IUATLD.Results Totally 1 014 TB cases were enrolled.The total DR rate was 19.8% and total multi-drug resistance(MDR) rate was 4.6%.The initial DR rate was 17.9% and initial MDR rate was 3.4%.The acquired DR rate was 44.0% and acquired MDR rate was 20.0%.Conclusion The prevalence of drug-resistant tuberculosis in Fujian province was lower than that of the average national level but higher than average international level,suggesting the necessity to strengthen the DR tuberculosis control program.
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Key words:
- tuberculosis /
- drug resistance /
- surveillance /
- Fujian province
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[1] 卫生部疾病预防控制局,卫生部医政司,中国疾病预防控制中心.中国结核病防治规划实施工作指南(2008 年版) [S].北京:中国协和医科大学出版社,2009. [2] 中国防痨协会基础专业委员会.结核病诊断实验室检验规程[S].北京:中国教育文化出版社,2006. [3] World Health Organization/International Union Against Tuberculosis and Lung Diseases,Guidelines for surveillance of drug resistance in tuberculosis[R].Geneva:WHO,1997. [4] 全国耐药结核病学术研讨会纪要[J].中华结核和呼吸杂志,2002,23(2):79. [5] 中华人民共和国卫生部.全国结核病耐药性基线调查报告(2007-2008年) [R].北京:人民卫生出版社,2010. [6] 邹盛华,代腊梅,张丽水.1008例初治菌阳肺结核患者的初始耐药情况分析[J].海峡预防医学杂志,2004,10(4):5-8. [7] 郑蓉蓉,张向东,黄成基.875株结核分枝杆菌耐药情况分析[J].现代预防医学,2008,35(23):4697-4698. [8] 钟球,钱明,李伟建,等.广东省WHO结核病耐药监测研究[J].中国防痨杂志,2001,23(1):5-8. [9] 李国明,曼必荣,张缇,等.湖北省结核分枝杆菌耐药性监测研究[J].中华结核和呼吸杂志,2002,25(12):723-726. [10] 杜长梅,王国斌,徐吉英,等.河南省第二轮结核病耐药监测及耐药趋势研究[J].中国防痨杂志,2006,28(2):95-100. [11] 李国刚,董彬,王峰,等.复治肺结核病例分枝杆菌分离株药敏试验分析[J].中国公共卫生,2006,22(12):1529. [12] 缪梓萍,李群,何海波,等.浙江省耐药结核病现状及趋势研究[J].中国防痨杂志,2007,29(3):215-218. [13] 安燕生,丁北川,朱建华,等.北京市WHO结核病药物耐药性监测研究[J].中国防痨杂志,2007,29(6):475-478. [14] 贾卫,吴卫东,张伟,等.WHO 新疆结核病耐药监测报告[J].中国防痨杂志,2008,30(4):307-310. [15] 谢艳光,李发斌,闫兴录.黑龙江省WHO结核病耐药监测报告[J].中国防痨杂志,2008,30(5):395-398. [16] 东洋,于梅,平国华.宁波地区流动人口结核病耐药状况分析[J].中国公共卫生,2011,27(4):394-395. [17] WHO/IUATLD.The WHO/IUATLD Global project on anti-tuberculosis drug resistance surveillance.Anti-tuberculosis drug resistance in the world[R].Genera:WHO,2008. -
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