Abstract: Objective To investigate the correlation between polymorphism of serotonin transporter（ 5-HTT） gene and asthma among Zhuang residents in Guangxi. Methods A case-control study was conducted in 188 asthma cases and 203 healthy controls selected from Zhuang nationality people in Guangxi. The loci of rs140700,rs2020936,rs3794808, rs6352,5-HTTLPR / rs25531,and Stin2 were genotyped. Psychological status of the participants was measured with Irritability,Depression and Anxiety Scale（ IDA）,Trait Coping Style Questionnaire（ TCSQ）,and Social Support Rating Scale（ SSRS）. Unconditional logistic regression analysis was applied to analyze the risk of asthma among different genotype carriers and their interaction with social-psychological factors. Results Univariate logistic regression analyses showed that risk of asthma was significantly increased for carriers of TT genotype than that of CC genotype individuals（ odds ratio OR=2. 33,95% confidence interval95% CI: 1. 04- 5. 20,P = 0. 039） for rs3794808. Multivariate logistic regression analyses indicated that polymorphism of loci of rs140700,rs2020936 and rs379480 were associated with asthma. Compared with those with genotype CC,the risk of suffering from asthma for genotype（ CT + TT） carriers was 2. 14 folds（ 95% CI: 1. 11- 4. 13,P = 0. 027） for rs140700. Compared with those with genotype AA,the risk of asthma for genotype AG and（ AG + GG） carriers was 1. 94 folds（ 95% CI: 1. 15- 3. 25） and 1. 74 folds（ 95% CI: 1. 05- 2. 88, P = 0. 033） for rs2020936. Compared with those with genotype TT,the risk of asthma for genotype CC carriers was 2. 83 folds（ 95% CI: 1. 15- 6. 98,P = 0. 024） for rs3794808. Polymorphism of rs140700 may interact with the score of depression and subjective support while polymorphism of rs2020936 may interact with score of irritability. Conclusion Polymorphism of rs140700,rs2020936,rs3794808 of 5-HTT may be the potential genetic susceptibility loci of asthma for Zhuang residents in Guangxi.