Abstract: Objective To investigate situation and risk factors of hepatitis B virus(HBV)infection among residents of Quanzhou city.Methods With multi-stage stratified random sampling,we selected 2 608 residents at age of 1-59 years in Jinjiang,Nan'an and Anxi areas of Quanzhou city.A pre-designed questionnaire was used and the blood sample was collected to test HBV infection.Results The infection rate of HBV in the population was 64.03%.The infection rates of HBV among the residents of different age,living area,occupation,and education were significantly different(P<0.01).The rate of hepatitis B vaccination was 21.80%.There were significant differences(χ²=1 371.79,P<0.001)in the rates of hepatitis B vaccination among the residents at age of 1-4(93.33%),5-14(60.14%),and 15-59 years(4.99%).The HBV infection rate of the people with hepatitis B vaccination was 13.66% and lower than those of without hepatitis B vaccination (χ²=805.48,P<0.001).Logistic analyses showed that oral treatmens,shaving at barkers'were main risk factors and immunization and age were the protective factors of HBV infeetion.Conclusion The rate of HBV infection is relatively high among the population of Quanzhou city.The rate of HBV infection for those with oral treatment or shaving at barkers is higher than that of without the exposures.Hepatitis B vaccination is an important measure to control HBV infection.