Abstract: Objective To investigate the relationship between serum resistin concentration and hyperuricemia among Uygur in Xinjiang Uygur Autonomous Region.Methods Serum resistin concentration was measured in 413 Uygur(207 hyperuricemia cases and 206 healthy controls)with enzyme-linked immunosorbent assay(ELISA)and their serum uric acid (SUA),triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL-C),low-density lipoproteincholesterol(LDL-C),height,body weight,waist circumference(WC),and hip circumference(HC)were also measured and their waist-to-height ratio(WHTR)and body mass index(BMI)were calculated.Results The WC,HC,WHTR,TG and systolic blood pressure(SBP)levels were significantly increased in hyperuricemia group compared with those of the control group.Resistin level in hyperuricemia group was significantly higher than that of in the control group(P<0.01).There was no difference in resistin level between two groups after adjustment for body fat.In control group,the level of resistin was not difference between male and female(PM>0.01).The serum resistin concentration was significantly and positively correlated with SUA(r=0.041,P=0.004).But resistin was not significantly correlated with age and blood pressure.BMI and LDL-C were significantly correlated with resistin based on the results of stepw ise linear regression(P<0.05).Conclusion The strong correlation between serum resistin and lipid metabolism suggests that lipid metabolism might be a intermediator between serum resistin and hyperuricemia in Uygur.