Abstract: Objective To assess the influence factors of International HIV-Associated Dementia Scale(IHDS)among AIDS patients in Guangxi Zhuang Autonomous Region and to provide eveidence for specific intervention. Methods From November 2010 to March 2011,100 human immunodeficiency virus(HIV)positive patients aged＜65 years were selected, excluding the patients with nervous system infection,cerebrovascular disease,major depression,and alcohol and substance abuse,from the Fourth Peoplies Hospital of Nanning City and surveyed with IHDS and Mini-Mental State Examination (MMSE)by trained neurolegists. Results The average IHDS score was 8.06±1.81 among the patients.The score of the patients equal or less than 50 years old was higher than that of 51-64 years old(9.79±1.94 vs 8.04±2.03;t=2.590, P=0.010).The score of the Han patients was higher thant that of Zhuang patients(9.56±1.70 vs 8.93±1.80; t=-9.329,P=0.041).The patients with the education under primary school had a lower score than those with the education equal or higher than primary school(7.33±1.37 vs 9.49±1.62;t=-7.861,P=0.000).Compared with the patients without history of alcohol drinking,the patients with alcohol drinking showed lower IHDS score(8.41±1.54 vs 9.27±1.83;t=3.301,P=0.030).There were no differences in the scores betweeen the ptients of different gender and smoking status(P>0.05 for all).The results of multivariate logistic regression showed that the age and the amount of alcohol consumption were negatively associated with and the education level was positively assciated with the IHDS score among the patients. Conclusion Age,educational level,alcohol consumption are major infulence factors of IHDS score.