Abstract: Objective To analyze the correlations of soluble interleukin 2 receptor(sIL-2R)and interleukin 2 (IL-2)serum levels with life event and coping style in depression patients. Methods Sixty drug-naive depressed patients were recruited and assessed with Life Event Scale(LES),Coping Style Questionnaire,and Haniltion Depression Scale(HAMD).sIL-2R and IL-2 levels were evaluated using enzyme-linked immunosorbent assay(ELISA)method in the patients and 60 healthy controls. Results The drug-naive depression patients had significantly lower serum IL-2 level than control group(P=0.025).The coping style and the score of LES were not correlated with sIL-2R and IL-2 levels among the patients(P>0.05).Compared with the controls,the patients experienced more stressful life events and used more immature coping styles(P<0.05). Conclusion There may be a decreased serum IL-2 level for depression patients.The levels of serum sIL-2R and IL-2 were not correlated with the score of life event and coping style.