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邹团标, 姚莉琴, 李智, 徐咏梅, 陆克文, 何磊, 周凤珍, 刘锦桃, 郭光萍. 中国云南省23个民族育龄人群地中海贫血基因检测与分析[J]. 中国公共卫生, 2019, 35(11): 1505-1510. DOI: 10.11847/zgggws1117281
引用本文: 邹团标, 姚莉琴, 李智, 徐咏梅, 陆克文, 何磊, 周凤珍, 刘锦桃, 郭光萍. 中国云南省23个民族育龄人群地中海贫血基因检测与分析[J]. 中国公共卫生, 2019, 35(11): 1505-1510. DOI: 10.11847/zgggws1117281
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Tuan-biao ZOU, Li-qin YAO, Zhi LI, . Detection of thalassemia genes among 23 ethnic reproductive populations in Yunnan province, China[J]. Chinese Journal of Public Health, 2019, 35(11): 1505-1510. DOI: 10.11847/zgggws1117281
Citation: Tuan-biao ZOU, Li-qin YAO, Zhi LI, . Detection of thalassemia genes among 23 ethnic reproductive populations in Yunnan province, China[J]. Chinese Journal of Public Health, 2019, 35(11): 1505-1510. DOI: 10.11847/zgggws1117281
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中国云南省23个民族育龄人群地中海贫血基因检测与分析

Detection of thalassemia genes among 23 ethnic reproductive populations in Yunnan province, China

    摘要
  • 摘要:
      目的  探讨云南省3个地中海贫血（以下简称地贫）高发地区23个少数民族育龄人群地中海贫血常见基因携带状况。
      方法  对西双版纳州、德宏州和文山州2012 — 2014年婚检、孕前和产前共21 317名育龄夫妇进行血细胞分析和血红蛋白电泳分析筛查及地贫基因诊断，用统计学方法分析育龄人群基因检出情况。
      结果  地中海贫血基因检出712例（3.3 %），经统计学检验3地区检出率差异有统计学意义；23个民族中检出率阿昌族为8.8 %，傣族为8.4 %，基诺族为8.2 %，布朗族为6.6 %，景颇族为5.0 %，拉祜族为4.9 %，壮族为4.5 %，瑶族为4.5 %；经logistic逐步回归分析，模型检验χ2 = 42.482，P = 0.000，模型有统计学意义，地区和民族是地中海贫血的危险因素，其相对危险度比值地区OR = 1.295，95 % CI = 1.118～1.498，民族OR = 1.029，95 % CI = 1.013～1.045。
      结论  云南省3个地贫高发区23个民族育龄人群地中海贫血基因携带率较高，具有地区和民族分布特点，本研究为地中海贫血的防控和干预提供最直接的理论依据。

     

    Abstract:
      Objective  To investigate the prevalence of common genes associated with thalassemia among 23 ethnic populations at childbearing age in 3 regions with high incidence of thalassemia in Yunnan province.
      Methods  Using blood cell count and hemoglobin electrophoresis, we conducted thalassemia screenings among 21 317 ethnic minority examinees of premarital, preconception, and prenatal check-up in Xishuangbanna, Dehong and Wenshan prefectures of Yunnan province from 2012 through 2014. Detections of common genes associated with thalassemia were also performed for all the examinees and the detection results were analyzed statistically.
      Results  Among the examinees, 712 were positive for thalassemia-related genes, with an overall detection rate of 3.3% and a significant regional difference in the detection rate. Thalassemia-related gene positive examinees were detected among 18 of 23 ethnic populations and higher detection rates were observed in ethnic minority populations of Achang (8.8%), Dai (8.4%), Jinuo (8.2%), Brown (6.6%), Jingpo (5%), Lahu (4.9%), Zhuang (4.5%), and Yao (4.5%). A step-wised logistic regression model was constructed successfully (χ2 = 42.482, P < 0.000), indicating that significant risk factors for thalassemia were region (odds ratio OR = 1.295, 95% confidence interval CI: 1.118 – 1.498) and ethnicity (OR = 1.029, 95% CI: 1.013 – 1.045).
      Conclusion  The carrying rate of common genes associated with thalassemia is relatively high among ethnic populations at childbearing age in 3 regions with high incidence of thalassemia in Yunnan province and differs by region and ethnicity. The results provide direct evidences for the prevention and intervention on thalassemia in the populations.

     

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