Abstract: An artificial intelligence technology-based provincial-level large-scale data computing center has been established in Guizhou Provincial Center for Disease Control and Prevention for early detection and management of infectious disease clustering in schools. Standardized processing on all infectious disease incidence records previously reported in the province by medical personnel in medical institutions at various levels was performed by the computing system through machine self-learning. Artificial intelligence-based early screening and warning of infectious disease clustering in schools were realized with automatic perception technology. Real time supervision and regulation on disease epidemic management were carried out with dynamic data visualization technology. All the artificial intelligence technologies have been preliminarily applied and played an important role in infectious diseases control and prevention since 2016 in the province.