Abstract:
Objective To explore treatment effect and risk factors of mortality among patients with pulmonary tuberculosis (TB) with directly observed treatment short-course (DOTS) in Tianjin municipality and to provide evidences for reducing TB-related mortality.
Methods From National TB Management Information System, we retrieved clinical data and treatment outcome among 5 052 TB patients registered in Tianjin municipality and with DOTS from 2014 through 2016 and analyzed the data retrospectively. Kaplan-Meier method and multivariate Cox proportional risk regression model were used to analyze the risk factors of mortality during DOTS.
Results For all the patients, the success rate of DOTS was 90.40% and the mortality rate was 4.67%. Cox regression analysis revealed that at older age, human immunodeficiency virus (HIV)-positive, first sputum smear-positive for Mycobacterium tuberculosis (MT), being retreated, and with a delayed seeking medication of 14 day or more were risk factors of mortality during DOTS in the TB patients; while, being female was protective factor against mortality during DOTS.
Conclusion During 2014 – 2016 among TB patients registered in Tianjin municipality, the outcome of DOTS was good and the patients being male, at older age, HIV-positive, first sputum smear-positive for Mycobacterium tuberculosis (MT), being retreated, with a delayed seeking medication of 14 day or more were at a higher mortality risk.
下载: