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杨阳, 朱志鸿, 张行易, 崔建兰, 许巍, 吴超群, 田娜, 任晶晶, 陈杨, 路甲鹏. 中国东北地区35~75岁成人心血管疾病高危风险特征和预防性药物使用[J]. 中国公共卫生, 2021, 37(10): 1483-1488. DOI: 10.11847/zgggws1133293
引用本文: 杨阳, 朱志鸿, 张行易, 崔建兰, 许巍, 吴超群, 田娜, 任晶晶, 陈杨, 路甲鹏. 中国东北地区35~75岁成人心血管疾病高危风险特征和预防性药物使用[J]. 中国公共卫生, 2021, 37(10): 1483-1488. DOI: 10.11847/zgggws1133293
YANG Yang, ZHU Zhi-hong, ZHANG Xing-yi, . Prevalence of high cardiovascular risk and preventive medication in residents aged 35 – 75 years in Northeastern China: an analysis on population screening data[J]. Chinese Journal of Public Health, 2021, 37(10): 1483-1488. DOI: 10.11847/zgggws1133293
Citation: YANG Yang, ZHU Zhi-hong, ZHANG Xing-yi, . Prevalence of high cardiovascular risk and preventive medication in residents aged 35 – 75 years in Northeastern China: an analysis on population screening data[J]. Chinese Journal of Public Health, 2021, 37(10): 1483-1488. DOI: 10.11847/zgggws1133293

中国东北地区35~75岁成人心血管疾病高危风险特征和预防性药物使用

Prevalence of high cardiovascular risk and preventive medication in residents aged 35 – 75 years in Northeastern China: an analysis on population screening data

  • 摘要:
      目的  描述中国东北地区心血管病高危人群特征、危险因素分布及预防用药情况,为制定心血管病精准防控策略提供数据参考。
      方法  以2014 — 2019年东北地区黑龙江、吉林、辽宁3个省份26个区县中414 346名35~75岁的常住居民为研究人群,计算人群整体以及根据年龄、性别、地区、社会经济特征分组后的高危对象检出比例,并应用多元混合模型评价个体特征与心血管病风险之间的关联,同时选择指南推荐的预防用药(他汀类药物和阿司匹林)来评价高危人群中的治疗情况。
      结果  在中国东北地区35~75岁的414 346名调查对象中,8.9 %为心血管病高危对象,这一比例在男性中和农村地区相对更高。混合模型结果显示,高学历、已婚、有医疗保险的人群更不易患心血管病;高收入(家庭年收入 > 50 000元)人群更倾向于是心血管病高危对象。在高危人群中,报告正在服用他汀类药物和阿司匹林的比例均为0.4 %。
      结论  在中国东北地区35~75岁的筛查对象中,接近9 %为心血管病高危对象,指南推荐的适宜使用他汀类药物和阿司匹林预防使用率均不足1 %。在这一人群中,降低心血管病风险势在必行。

     

    Abstract:
      Objective  To describe the characteristics of risk factors and the usage of prevention drugs for cardiovascular diseases (CVD) among adult residents in Northeastern China and to provide evidence data for developing strategies on precise prevention and control of cardiovascular diseases.
      Methods   From the dataset of Patient-Centered Evaluative Assessment of Cardiac Events (PEACE) conducted across China from 2014 to 2019, we extracted the data on 414 346 permanent residents aged 35 – 75 years in 26 county-level regions in 3 northeastern provinces of China. The overall and age-, sex-, geographic region-, and socioeconomic status-specific ratio of people at high of CVD risk were calculated for the participants. Multivariate mixed model was adopted to assess associations of individual characteristics with CVD risk factors. The usage of statins and aspirin recommended in China′s national guidelines for CVD prevention was also analyzed to evaluate CVD preventive medication among the participants at high CVD risk.
      Results   Of all the participants, 8.9% were identified as individuals at high risk of CVD, and the ratio was relatively higher among the male and rural participants. Mixed model analysis revealed that the participants with higher education, being married and with medical insurance were less likely to be at high risk of CVD but those with an annual household income of 50 000 Yuan RMB were more likely to be at high risk of CVD. Of the participants with high CVD risk, only 0.4% reported taking both statins and aspirin currently.
      Conclusion   Among the 35 – 75 years old permanent residents in Northern China, nearly 9% are individuals at high risk of cardiovascular diseases; whereas, less than 1% of the high risk individuals have current medication of statins and aspirin recommended by national guidelines for cardiovascular disease prevention, suggesting that relevant interventions should be promoted among the high risk population for the prevention of the diseases.

     

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