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孕妇外周血及脐带血红细胞甲基汞含量孕期内变化情况检测分析

陈星 罗佳瑶 陈欢 陈曦 李媛媛

陈星, 罗佳瑶, 陈欢, 陈曦, 李媛媛. 孕妇外周血及脐带血红细胞甲基汞含量孕期内变化情况检测分析[J]. 中国公共卫生, 2022, 38(8): 1058-1061. doi: 10.11847/zgggws1136158
引用本文: 陈星, 罗佳瑶, 陈欢, 陈曦, 李媛媛. 孕妇外周血及脐带血红细胞甲基汞含量孕期内变化情况检测分析[J]. 中国公共卫生, 2022, 38(8): 1058-1061. doi: 10.11847/zgggws1136158
CHEN Xing, LUO Jia-yao, CHEN Huan, CHEN Xi, . Changes in erythrocyte methylmercury among women during pregnancy: a monocentric survey and comparison study[J]. Chinese Journal of Public Health, 2022, 38(8): 1058-1061. doi: 10.11847/zgggws1136158
Citation: CHEN Xing, LUO Jia-yao, CHEN Huan, CHEN Xi, . Changes in erythrocyte methylmercury among women during pregnancy: a monocentric survey and comparison study[J]. Chinese Journal of Public Health, 2022, 38(8): 1058-1061. doi: 10.11847/zgggws1136158

孕妇外周血及脐带血红细胞甲基汞含量孕期内变化情况检测分析

doi: 10.11847/zgggws1136158
基金项目: 国家自然科学基金(42077398)
详细信息
    作者简介:

    陈星(1999 – ),男,贵州安顺人,本科在读,研究方向:环境与健康方面

    通讯作者:

    李媛媛,E-mail:liyunayuan@hust.edu.cn

  • (罗佳瑶为本文并列第一作者)
  • 中图分类号: R 12

Changes in erythrocyte methylmercury among women during pregnancy: a monocentric survey and comparison study

  • 摘要:   目的  调查普通孕妇不同孕期外周血及新生儿脐带血红细胞中甲基汞浓度变化及相关性。  方法  于2019年1 — 4月在湖北省武汉市招募79名孕妇,采集孕妇孕早期[孕(12 ± 2)周]和孕晚期[孕(37 ± 2)周]外周血及新生儿脐带血,分离红细胞,采用高效液相色谱 – 电感耦合等离子体质谱联用方法检测红细胞内甲基汞浓度。  结果  本研究孕妇孕早、晚期及脐带血红细胞中甲基汞浓度的几何均数分别为0.322、0.238、0.515 μg/g,四分位数间距分别为0.188~0.728、0.120~0.549、0.322~1.099 μg/g,孕早期甲基汞含量显著高于孕晚期(P < 0.05),孕晚期甲基汞含量显著低于脐带血(P < 0.05),孕早期甲基汞含量也显著低于脐带血(P < 0.05),孕早、晚期血及脐带血甲基汞含量之间两两呈现强正相关性(r = 0.763、0.866、0.854)。  结论  孕妇孕早期、孕晚期血和新生儿脐带血红细胞中甲基汞含量存在明显相关性;脐带血红细胞甲基汞含量显著高于孕妇外周血,提示可能存在富集现象。
    1)  (罗佳瑶为本文并列第一作者)
  • 表  1  孕妇不同孕期外周血和新生儿脐带血红细胞汞含量分布(μg/g)

    时期GP25P75M范围
    孕早期 0.322 0.188~0.728 a 0.421 0.014~1.652
    孕晚期 0.238 0.120~0.549 b 0.341 0.006~1.890
    脐带血 0.515 0.322~1.099 c 0.704 0.018~2.691
      注:与孕晚期比较,a P < 0.05;与脐带血比较,b P < 0.05;与孕早期比较,c P < 0.05。
    下载: 导出CSV

    表  2  孕妇不同孕期外周血和新生儿脐带血红细胞汞含量相关系数

    样本孕早期孕晚期脐带血
    孕早期1.0000.763 a0.854 a
    孕晚期1.0000.866 a
    脐带血1.000
      注:a P < 0.05。
    下载: 导出CSV

    表  3  各地区脐带血与母血汞含量比值比较

    汞含量地区脐带血(μg/L)母血(μg/L)比值
    总汞 Arctic Canada[7] 5.80(2.7) 2.96(1.66) 1.49(1.40)
    Bochum Germany[8] 1.48 0.44 3.36
    South African[9] 1.20 0.65 1.85
    Eastern Slovakia[10] 0.53 0.50 1.24
    松原市[11] 2.87(2.66) 1.58(1.34) 2.28
    山东省[12] 1.21 0.68 1.73
    韩国[13] 5.87 3.99 1.47
    甲基汞 Arctic Canada[7] 4.90(2.5) 2.20(1.3) 1.86(1.64)
    Eastern Slovakia[10] 0.32 0.22 1.80
    武汉[本研究孕早期] a 0.75(0.52) 0.48(0.32) 1.96(1.56)
    武汉[本研究孕晚期] a 0.75(0.52) 0.40(0.24) 2.90(1.89)
      注:括号外为算数均数,括号内为几何均数;a 本研究为红细胞甲基汞(μg/g)。
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-07-12
  • 网络出版日期:  2022-07-22
  • 刊出日期:  2022-08-31

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