云南玉溪市老年人23价肺炎球菌多糖疫苗免费接种安全性分析

马运葵; 祁昆; 刘正楠; 吴丽清; 杨晓娟; 李廷学; 任志艳; 杨晶; 艾敏; 吴强

doi:10.11847/zgggws1137123

云南玉溪市老年人23价肺炎球菌多糖疫苗免费接种安全性分析

Safety of free vaccination of 23 valent pneumococcal polysaccharide vaccine among elderly residents in Yuxi city, Yunnan province: a monitoring data analysis

摘要

摘要:
目的了解云南省玉溪市 ≥ 60岁老年人免费接种23价肺炎球菌多糖疫苗（PPV23）的安全性，为当地开展肺炎球菌多糖疫苗的接种工作提供参考依据。
方法收集云南省疑似预防接种异常反应（AEFI）监测信息管理系统中2018年1月1日 — 2020年12月31日玉溪市老年人免费接种PPV23的AEFI数据，对AEFI的发生情况、发生时间、发生程度和病例转归情况进行了描述性分析。
结果玉溪市2018年1月1日 — 2020年12月31日免费接种PPV23的 ≥ 60岁老年人共243670人，累计报告AEFI者40例，AEFI发生率为16.42/10万；其中一般反应占77.5 %，异常反应占12.5 %，心因性反应和偶合反应分别占5 %，上述病例均好转与痊愈。
结论玉溪市老年人免费接种PPV23的安全性良好。

Abstract:
Objective To evaluate the safety of 23 valent pneumococcal polysaccharide vaccine (PPV23) vaccination in elderly residents of Yuxi city, Yunnan province for providing a reference to the promotion of PPV23 vaccination in local elderly population.
Methods The data on adverse events following immunization (AEFI) of free PPV23 vaccination among the 60 years old and above residents in Yuxi city from January 2018 through December 2020 were collected from the Yunnan Province AEFI Monitoring Information Management System and analyzed with descriptive statistics.
Results Free PPV23 vaccination was performed among a total of 243 670 elderly residents in the city during the 3-year period. Among the elderly vaccinated, 40 AEFI were reported, with an incidence rate of 16.42/100 000. Of all the reported AEFI, 77.5% were general reactions; 12.5% were abnormal reactions, and 5% were psychogenic and coupling reactions, respectively. All the AEFI cases were improved or cured one month after the incidence of AEFI.
Conclusion Free vaccination of 23 valent pneumococcal polysaccharide vaccine is safe among residents aged 60 years and above in Yuxi city.

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