Objective  To examine the influence of stroke risk factors on cerebrovascular function in adult outpatient attendees and to provide a reference for the prevention and control of stroke.

  Methods  Questionnaire survey and screening on stroke risk with a cerebrovascular function detector were conducted among 85 532 adult outpatient attendees ( ≥ 20 years old) recruited using cluster sampling at a hospital in Wuhan city, Hubei province from October 2016 to July 2021. Unconditional multivariate logistic regression analysis was performed to explore the impact of risk factors for stroke on cerebrovascular function (function score).

  Results  Complete information were collected from a total of 83 742 participants (41 776 males and 41 966 females) aged 58.58 ± 13.29 years. For all the participants, the average cerebrovascular function score was 74.98 ± 23.30 in a scale from 1 to 100 and 29 313 (35.00%) of the participants had a cerebrovascular function score of less than 75, indicating with a high risk of stroke. The results of logistic regression analysis showed that being female, aged ≥ 45 years, with a body mass index (BMI) of ≥ 18.5, suffering from hypertension, diabetes mellitus and cardiovascular disease were independent risk factors for with a high risk of stroke. The cerebrovascular function score, mean cerebral blood flow (CBF) rate and minimum CBF rate were lower but the peripheral resistance and critical pressure of CBF were higher among the participants at older age, with a higher BMI, and having hypertension, diabetes, and cardiovascular disease. The critical pressure of CBF were lower among female participants than that among male participants.

  Conclusion  Being at a high risk of stroke is associated with low cerebrovascular function score, mean and minimum CBF rate, and high CBF peripheral resistance and critical pressure among adult physical examinees.