男性静坐时长与精液质量关联性

张丽; 袁冠湘; 刘佩意; 刘瑜; 邹飞; 程锦泉

doi:10.11847/zgggws1137843

男性静坐时长与精液质量关联性

doi: 10.11847/zgggws1137843

张丽^{1, 2},
袁冠湘^2, ,,
刘佩意³,
刘瑜⁴,
邹飞¹,
程锦泉^{1, 2, ,}

1.
南方医科大学公共卫生学院，广东广州 510515
2.
深圳市疾病预防控制中心
3.
南方医科大学附属深圳妇幼保健院
4.
深圳市人民医院

基金项目: 国家自然科学基金（21806113）; 深圳市医疗卫生“三名工程项目”（SZSM201511007）

详细信息

作者简介:
张丽（1997 – ），女，安徽阜阳人，硕士在读，研究方向：公共卫生

通讯作者:
袁冠湘，E-mail：manshashuhua@163.com

程锦泉，E-mail：cjinquan@szcdc.net

中图分类号: R 698.2
计量
- 文章访问数: 360
- HTML全文浏览量: 127
- PDF下载量: 49
- 被引次数: 0
出版历程
- 接收日期: 2021-12-28
- 网络出版日期: 2022-08-31
- 刊出日期: 2022-12-10

Association between sedentary time and semen quality in adult men: a hospital-based cross-sectional survey

ZHANG Li^{1, 2},
YUAN Guan-xiang^{2
, ,},
LIU Pei-yi³,

1.
School of Public Health, Southern Medical University, Guangzhou, Guangdong Province 510515, China

摘要

摘要: 目的探究男性静坐时长与主要精液质量参数的相关性。方法采用横断面研究方法，招募2017 — 2019年在深圳市某医院生殖中心进行生育咨询的4 532名男性进行问卷调查，采用计算机辅助精液分析设备检测精液质量常规参数（精子总数、精子浓度、总活动率、前向运动率），采用二元logistic回归模型分析静坐时长与精液质量参数间的关系。结果精子前向运动率：与静坐时长 < 4 h/d组[（55.29 ± 19.15）%]相比，静坐时长 ≥ 8 h/d组[（53.18 ± 19.59 %）]较低，差异有统计学意义（F = 2.96，P < 0.05）；精子总活动率：与静坐时长4 h/d ～组[（66.57 ± 19.50 %）]相比，静坐时长 ≥ 8 h/d组（64.30 ± 20.16 %）较低，差异有统计学意义（F = 3.19，P < 0.05）。logistic回归结果显示，未校正混杂因素时，静坐时长 ≥ 8 h/d组精子前向运动率降低的风险[OR（95 %CI）]是 < 4 h/d组的1.28倍（1.02～1.60）；校正混杂因素后,静坐时长 ≥ 8 h/d组仍与精子前向运动率的下降风险增加有关（P < 0.05）。结论久坐（ ≥ 8 h/d）是男性精子前向运动率下降的风险因素。
- 久坐 /
- 精液质量 /
- 体力活动 /
- 流行病学研究
Abstract: Objective To investigate the relationship between semen quality and sedentary time. Methods A cross-sectional survey was conducted among 4 532 men (aged 18 – 60 years) seeking fertility consultation at a reproductive center of a hospital in Shenzhen city from March 2017 through May 2019. Questionnaire interview and semen sampling were carried out among the participants. Routine indicators of semen quality were determined with a computer assisted semen analysis system (CASA) and the relationship between sedentary time and semen quality indicators was assessed with binary logistic regression analysis. Results In comparison to those in the participants reporting the sedentary time of less than 4 hours per day, significantly lower sperm progressive motility rate (53.18 ± 19.59% vs. 55.29±19.15%, F = 2.96; P < 0.05) and total sperm motility rate (64.30 ± 20.16% vs. 66.57 ± 19.50%, F = 3.19; P < 0.05) were detected in the men reporting the sedentary time of 8 hours and above per day. The results of logistic regression analysis showed that compared to those with the sedentary time of less than 4 hours per day, the participants with the sedentary time of 8 hours and above per day were at a significantly increased risk of having a reduced sperm progressive motility (odds ratio = 1.29, 95% confidence interval: 1.03 – 1.62) after adjusting for age, body mass index, days of abstinence, smoking, alcohol drinking, and time of physical activity. Conclusion Prolonged sedentary time (≥ 8 h/day) is a risk factor for decreased sperm progressive motility in adult men.
- sedentary behavior /
- semen quality /
- physical activity /
- epidemiological study

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表 1 研究人群一般人口学特征及每日静坐时长分布

变量	人数	%	每日静坐时间（h）								χ²值	P 值
			< 4		4～		6～		≥ 8
			人数	%	人数	%	人数	%	人数	%
禁欲时间（d）											11.36	0.078
< 3	532	11.7	182	11.4	123	11.2	88	10.0	139	14.4
3～5	3196	70.5	1121	70.5	775	70.5	625	71.3	675	69.9
> 5	804	17.7	287	18.1	202	18.4	163	18.6	152	15.7
饮酒频率（次/周）											19.21	< 0.001
< 1	3791	83.6	1294	81.4	905	82.3	748	85.4	844	87.4
≥ 1	741	16.4	296	18.6	195	17.7	128	14.6	122	12.6
吸烟情况											108.09	< 0.001
从不吸烟	2393	52.8	704	44.3	553	50.3	531	60.6	605	62.6
吸烟	2139	47.2	886	55.7	547	49.7	345	39.4	361	37.4
运动时长（h/周）											82.11	< 0.001
0	2195	48.4	849	53.4	476	43.3	346	39.5	524	54.2
0～	444	9.8	158	9.9	117	10.6	90	10.3	79	8.2
1～	962	21.2	294	18.5	259	23.5	203	23.2	206	21.3
≥ 3	931	20.5	289	18.2 ^a	248	22.5 ^a	237	27.1	157	16.3 ^a
注：与6～组比较，a P < 0.001。

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表 2 每日不同静坐时间精液质量情况

静坐时间（h/d）	前向运动率（%）	精子浓度（ × 10⁶/mL）		精子总数（ × 10⁶/一次射精）		总活动率（%）
静坐时间（h/d）	前向运动率（%）	M	P₂₅～P₇₅	M	P₂₅～P₇₅	总活动率（%）
< 4	55.29 ± 19.15 ^a	69.4	39.0～111.3	255.6	137.2～406.7	66.50 ± 19.33 ^a
4～	55.28 ± 19.11 ^a	70.8	42.4～113.3	255.9	145.5～410.4	66.57 ± 19.50 ^a
6～	54.96 ± 18.92 ^a	73.8	44.5～116.6	265.9	151.0～428.2	66.11 ± 19.17 ^a
≥ 8	53.18 ± 19.59	73.3	41.0～119.5	248.9	138.7～423.4	64.30 ± 20.16
F 值	2.96	4.88		3.55		3.19
P 值	0.03	0.16		0.32		0.02
注：与 ≥ 8 h/d组比较，a P < 0.001。

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表 3 静坐时长与精子浓度的关联性

静坐时长（h/d）	对照组	β	$S_{\bar x}$	Wald χ²值	P 值	P_趋势值	OR 值	95 % CI
模型1	< 4					0.586
4～		– 0.26	0.15	2.85	0.091		0.77	0.57～1.04
6～		– 0.38	0.17	5.01	0.025		0.68	0.49～0.95
≥ 8		– 0.00	0.15	0.00	0.986		0.98	0.75～1.33
模型2	< 4					0.542
4～		– 0.25	0.15	2.70	0.100		0.78	0.58～1.05
6～		– 0.37	0.17	4.62	0.032		0.69	0.49～0.97
≥ 8		– 0.02	0.15	0.02	0.892		0.98	0.73～1.32
模型3	< 4					0.545
4～		– 0.24	0.15	2.44	0.118		0.79	0.58～1.06
6～		– 0.35	0.17	4.16	0.041		0.70	0.50～0.99
≥ 8		– 0.02	0.15	0.03	0.871		0.98	0.73～1.31
注：精子浓度赋值：0代表正常，1代表异常，采用enter法纳入变量；模型1是不校正任何混杂因素，模型2校正年龄、体质指数、禁欲时间、饮酒和吸烟，模型3是在模型2的基础上，把运动时长作为协变量纳入回归方程中。

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表 4 静坐时长与精子总数的关联性

静坐时长（h/d）	对照组	β	$S_{\bar x}$	Wald χ²值	P 值	P_趋势值	OR 值	95 % CI
模型1	< 4					0.700
4～		– 0.11	0.16	0.44	0.507		0.90	0.65～1.24
6～		– 0.49	0.20	6.13	0.013		0.61	0.42～0.90
≥ 8		0.06	0.16	0.15	0.70		1.07	0.78～1.46
模型2	< 4					0.658
4～		– 0.11	0.16	0.43	0.512		0.90	0.65～1.24
6～		– 0.48	0.20	5.70	0.017		0.62	0.42～0.92
≥ 8		0.04	0.17	0.07	0.791		1.05	0.76～1.44
模型3	< 4					0.656
4～		– 0.09	0.16	0.27	0.603		0.92	0.67～1.27
6～		– 0.44	0.20	4.89	0.027		0.64	0.43～0.95
≥ 8		0.04	0.17	0.04	0.83		1.04	0.75～1.43
注：精子总数赋值：0代表正常，1代表异常，采用enter法纳入变量；模型1是不校正任何混杂因素，模型2校正年龄、体质指数、禁欲时间、饮酒和吸烟，模型3是在模型2的基础上，把运动时长作为协变量纳入回归方程中。

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表 5 静坐时长与精子前向运动率的关联性

静坐时长（h/d）	对照组	β	$S_{\bar x}$	Wald χ²值	P 值	P_趋势值	OR 值	95 % CI
模型1	< 4					0.039
4～		– 0.03	0.12	0.05	0.824		0.97	0.77～1.23
6～		0.05	0.12	0.16	0.691		1.05	0.82～1.34
≥ 8		0.24	0.12	4.51	0.034		1.28	1.02～1.60
模型2	< 4					0.033
4～		– 0.04	0.12	0.10	0.753		0.96	0.77～1.21
6～		0.05	0.13	0.17	0.680		1.05	0.83～1.35
≥ 8		0.25	0.12	4.73	0.030		1.29	1.03～1.62
模型3	< 4					0.032
4～		– 0.03	0.12	0.06	0.806		0.97	0.77～1.22
6～		0.06	0.13	0.22	0.638		1.06	0.83～1.36
≥ 8		0.26	0.12	4.78	0.029		1.29	1.03～1.62
注：精子前向运动率赋值：0代表正常，1代表异常，采用enter法纳入变量；模型1是不校正任何混杂因素，模型2校正年龄、体质指数、禁欲时间、饮酒和吸烟，模型3是在模型2的基础上，把运动时长作为协变量纳入回归方程中。

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