Abstract: With rapid global outbreak and emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS - CoV - 2) variants, the coronavirus disease 2019（COVID - 19) pandemic will inevitably pose formidable challenges to the prevention and treatment of human immunodeficiency virus (HIV) infection, while pushing HIV positive individuals to a greater disadvantage. This article reviews the disease progression of HIV positive individuals infected with SARS - COV - 2, covering impacts of COVID - 19 on HIV positive individuals and AIDS patients' diagnosis/treatment and psychological condition to provide a reference for developing related researches and optimizing HIV prevention and treatment under the context of COVID - 19 pandemic.