高级检索

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

老年人血脂水平与阿尔茨海默病发病风险系统评价

吕旋瑞 徐静 林晓南 周锦 李旭晗 宗晓郁 宋晶 张灵健 李欣鑫 宫建

吕旋瑞, 徐静, 林晓南, 周锦, 李旭晗, 宗晓郁, 宋晶, 张灵健, 李欣鑫, 宫建. 老年人血脂水平与阿尔茨海默病发病风险系统评价[J]. 中国公共卫生, 2022, 38(8): 1066-1069. doi: 10.11847/zgggws1138716
引用本文: 吕旋瑞, 徐静, 林晓南, 周锦, 李旭晗, 宗晓郁, 宋晶, 张灵健, 李欣鑫, 宫建. 老年人血脂水平与阿尔茨海默病发病风险系统评价[J]. 中国公共卫生, 2022, 38(8): 1066-1069. doi: 10.11847/zgggws1138716
LÜ Xuan-rui, XU Jing, LIN Xiao-nan, SONG Jing, . Lipid level and risk of Alzheimer′s disease: a systematic review and meta-analysis[J]. Chinese Journal of Public Health, 2022, 38(8): 1066-1069. doi: 10.11847/zgggws1138716
Citation: LÜ Xuan-rui, XU Jing, LIN Xiao-nan, SONG Jing, . Lipid level and risk of Alzheimer′s disease: a systematic review and meta-analysis[J]. Chinese Journal of Public Health, 2022, 38(8): 1066-1069. doi: 10.11847/zgggws1138716

老年人血脂水平与阿尔茨海默病发病风险系统评价

doi: 10.11847/zgggws1138716
详细信息
    作者简介:

    吕旋瑞(1998 – ),女,吉林四平人,硕士在读,研究方向:药物流行病学与临床药物评价

    通讯作者:

    宫建,E-mail:fanxing1230@163.com

  • 中图分类号: R 183

Lipid level and risk of Alzheimer′s disease: a systematic review and meta-analysis

  • 摘要:   目的  系统评价多种血脂水平在预测阿尔茨海默病(AD)发病风险过程中的作用。  方法  检索中国知网数据库、万方数据知识服务平台、维普数据库、Pubmed、Web of Science、Springer、Cocharne Library,并辅以手工检索和文献追溯法收集建库至2021年6月国内外公开发表的关于血脂水平与AD发病风险的相关文献;按照纽卡斯尔-渥太华质量量表评价纳入研究的质量;用RevMan5.3软件对纳入的文献进行meta分析。  结果  按照纳入和排除标准共筛选出15篇符合要求的研究文献,收集1435名健康老年人以及2162例患有AD老年人的多种血脂水平。经过meta分析结果显示,AD组老年人的总胆固醇、甘油三酯水平与健康对照组老年人差异无统计学意义;低密度脂蛋白胆固醇(LDL-C)水平显著高于对照组(MD = 3.59,95 % CI = 0.98~6.21);高密度脂蛋白胆固醇(HDL-C)水平显著低于对照组(MD = – 3.47,95 % CI = – 5.94~– 0.99)。  结论  老年人LDL-C水平偏高以及HDL-C水平偏低预示可能将有更高的AD患病风险。
  • 图  1  文献筛选流程

    表  1  纳入的15篇文献的基本信息

    纳入研究及年份国家研究对象样本量年龄
    (岁,$\bar x \pm s$)
    HDL-C
    (mg/dL,$\bar x \pm s$)
    LDL-C
    (mg/dL,$\bar x \pm s$)
    TC
    (mg/dL,$\bar x \pm s$)
    TG
    (mg/dL,$\bar x \pm s$)
    2017[8]中国AD组11871.81 ± 9.6648.43 ± 13.9106.29 ± 50.5
    对照组12070.45 ± 9.5252.52 ± 13.1105.40 ± 38.1
    2012[9]中国AD组10477.8 ± 6.7451.43 ± 1295.13 ± 25.5173.24 ± 34.4120.46 ± 54.9
    对照组10476.5 ± 6.1455.68 ± 1292.81 ± 31.7158.55 ± 40.2116.92 ± 62.9
    2014[10]中国AD组4480.00 ± 8.92171.31 ± 40.2118.69 ± 68.2
    对照组6279.63 ± 7.85164.35 ± 48.0124.89 ± 85.9
    2014[11]中国AD组4869.32 ± 5.5345.9 ± 10.3138.2 ± 34.7
    对照组3771.06 ± 5.8757.8 ± 14.6136.8 ± 16.4
    2015[12]中国AD组20176.79 ± 5.6551.04 ± 13.9100.54 ± 24.2197.99 ± 37.9163.86 ± 99.2
    对照组25775.88 ± 6.5051.43 ± 29.895.13 ± 43.7188.32 ± 26.7175.38 ± 124.0
    2016[13]中国AD组20780.67 ± 8.18850.27 ± 13.1107.5 ± 34.4184.07 ± 41.4
    对照组25681.66 ± 6.38253.36 ± 15.9104.41 ± 38.7176.72 ± 48
    2005[14]中国AD组3569.1 ± 8.256.84 ± 11.6158.55 ± 34.42246.71 ± 41.8
    对照组1669.6 ± 6.955.3 ± 10.1141.53 ± 24.0222.35 ± 34.4
    2000[15]日本AD组3677.3 ± 4.969 ± 21110 ± 26194 ± 33103 ± 52
    对照组1571.8 ± 6.164 ± 19114 ± 36207 ± 40142 ± 96
    2017[16]日本AD组4280.5 ± 5.7118.8 ± 39.4199.3 ± 45.1119.1 ± 68.4
    对照组1875.6 ± 5.5119.2 ± 35.7211.1 ± 39.9140.7 ± 66.3
    2009[17]日本AD组19780 ± 1458 ± 14123 ± 2882 ± 42.0
    对照组4775 ± 6.8656 ± 20.6121 ± 27.486 ± 27.4
    2005[18]日本AD组10679 ± 7106 ± 34181 ± 3792 ± 50.0
    对照组22776 ± 10100 ± 37184 ± 41104 ± 42.0
    2005[19]土耳其AD组12074.0 ± 7.6129.1 ± 44.2213.9 ± 44.6147.1 ± 86.5
    对照组80371.4 ± 5.9130.3 ± 60.9212.0 ± 46.5144.7 ± 76.0
    2017[20]塞尔维亚AD组6273.1 ± 5.850.27 ± 11.6132.86 ± 62.0
    对照组4068.4 ± 5.561.48 ± 11.6141.72 ± 97.4
    2018[21]巴西AD组4078 ± 8.495.16 ± 25.01157.01 ± 24.91
    对照组4076.5 ± 7.688.57 ± 28.15165.32 ± 34.03
    2014[22]印度AD组7540.5 ± 9.5104.4 ± 28.8170.7 ± 31.7129.0 ± 43.7
    对照组12042.4 ± 8.3100.6 ± 21.8167.6 ± 22.8122.6 ± 31.3
    下载: 导出CSV
  • [1] Masters CL, Bateman R, Blennow K, et al. Alzheimer’s disease[J]. Nature Reviews Disease Primers, 2015, 1: 15056. doi: 10.1038/nrdp.2015.56
    [2] 王志会, 齐士格, 张晗, 等. 老年期重点疾病预防和干预项目设计与实施[J]. 中国公共卫生, 2021, 37(11): 1585 – 1589. doi: 10.11847/zgggws1133281
    [3] Ferri CP, Prince M, Brayne C, et al. Global prevalence of dementia: a Delphi consensus study[J]. The Lancet, 2005, 366(9503): 2112 – 2117. doi: 10.1016/S0140-6736(05)67889-0
    [4] Anstey KJ, Ashby-Mitchell K, Peters R. Updating the evidence on the association between serum cholesterol and risk of late-life dementia: review and meta-analysis[J]. Journal of Alzheimer′s Disease, 2017, 56(1): 215 – 228. doi: 10.3233/JAD-160826
    [5] Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses[J]. European Journal of Epidemiology, 2010, 25(9): 603 – 605. doi: 10.1007/s10654-010-9491-z
    [6] 张兴会, 陈明珠, 宗晓郁, 等. 药物流行病学研究中亚组分析和效应修饰的探讨[J]. 药物流行病学杂志, 2021, 30(9): 575 – 578, 595.
    [7] 王树月, 陈明珠, 张兴会, 等. 药物流行病学研究混杂因素的控制[J]. 药物流行病学杂志, 2021, 30(8): 503 – 507.
    [8] Li H, Zhou JX, Yue ZW, et al. A complex association between ABCA7genotypes and blood lipid levels in Southern Chinese Han patients of sporadic Alzheimer′s disease[J]. Journal of the Neurological Sciences, 2017, 382: 13 – 17. doi: 10.1016/j.jns.2017.09.016
    [9] Xiao ZJ, Wang J, Chen WR, et al. Association studies of several cholesterol-related genes (ABCA1, CETP and LIPC) with serum lipids and risk of Alzheimer’s disease[J]. Lipids in Health and Disease, 2012, 11: 163. doi: 10.1186/1476-511X-11-163
    [10] Chang L, Wang YL, Ji HH, et al. Elevation of peripheral BDNF promoter methylation links to the risk of Alzheimer′s disease[J]. PLoS One, 2014, 9(11): e110773. doi: 10.1371/journal.pone.0110773
    [11] Zhao Z, Zhou H, Peng Y, et al. Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer′s disease[J]. Genetics and Molecular Research, 2014, 13(4): 8428 – 8435. doi: 10.4238/2014.October.20.19
    [12] Yu ZL, Li W, Hou DR, et al. Relationship between adiponectin gene polymorphisms and late-onset Alzheimer’s disease[J]. PLoS One, 2015, 10(4): e0125186. doi: 10.1371/journal.pone.0125186
    [13] Zheng JQ, Yan HC, Shi L, et al. The CYP19A1 rs3751592 variant confers susceptibility to Alzheimer disease in the Chinese Han population[J]. Medicine, 2016, 95(35): e4742. doi: 10.1097/MD.0000000000004742
    [14] 王春玉, 方莹莹, 褚文政, 等. 阿尔茨海默病及血管性痴呆患者血清胆固醇、Vit B12和叶酸变化的临床研究[J]. 中国神经精神疾病杂志, 2005, 31(3): 188 – 191. doi: 10.3969/j.issn.1002-0152.2005.03.008
    [15] Wada H. Analyses of serum concentrations of apolipoproteins in the demented elderly[J]. Internal Medicine, 2000, 39(3): 220 – 222. doi: 10.2169/internalmedicine.39.220
    [16] Kouzuki M, Nagano M, Suzuki T, et al. Cerebrospinal fluid biomarkers of Alzheimer′s disease are associated with carotid plaque score and hemodynamics in intra- and extra-cranial arteries on ultrasonography[J]. Journal of Clinical Neuroscience, 2018, 49: 32 – 36. doi: 10.1016/j.jocn.2017.12.006
    [17] Ban Y, Watanabe T, Suguro T, et al. Increased plasma urotensin-II and carotid atherosclerosis are associated with vascular dementia[J]. Journal of Atherosclerosis and Thrombosis, 2009, 16(3): 179 – 187. doi: 10.5551/jat.E608
    [18] Watanabe T, Miyazaki A, Katagiri T, et al. Relationship between serum insulin-like growth factor-1 levels and Alzheimer′s disease and vascular dementia[J]. Journal of the American Geriatrics Society, 2005, 53(10): 1748 – 1753. doi: 10.1111/j.1532-5415.2005.53524.x
    [19] Cankurtaran M, Yavuz BB, Halil M, et al. Are serum lipid and lipoprotein levels related to dementia?[J]. Archives of Gerontology and Geriatrics, 2005, 41(1): 31 – 39. doi: 10.1016/j.archger.2004.10.008
    [20] Macesic M, Lalic NM, Kostic VS, et al. Impaired insulin sensitivity and secretion in patients with Alzheimer’s disease: the relationship with other atherosclerosis risk factors[J]. Current Vascular Pharmacology, 2017, 15(2): 158 – 166. doi: 10.2174/1570161114666160905170644
    [21] Grossi MF, Carvalho MDG, Silveira JN, et al. OxLDL plasma levels in patients with Alzheimer′s disease[J]. Arquivos de Neuro-Psiquiatria, 2018, 76(4): 241 – 246. doi: 10.1590/0004-282x20180012
    [22] Alam R, Tripathi M, Mansoori N, et al. Synergistic epistasis of paraoxonase 1 (rs662 and rs85460) and apolipoprotein E4 genes in pathogenesis of Alzheimer′s disease and vascular dementia[J]. American Journal of Alzheimer’s Disease and Other Dementias, 2014, 29(8): 769 – 776. doi: 10.1177/1533317514539541
    [23] Li J, Wang YJ, Zhang M, et al. Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease[J]. Neurology, 2011, 76(17): 1485 – 1491. doi: 10.1212/WNL.0b013e318217e7a4
    [24] 宫建, 张灵健, 王树月, 等. 新公卫背景下循证药学教学模式探讨[J]. 中国公共卫生, 2021, 37(9): 1447 – 1448. doi: 10.11847/zgggws1136797
  • 加载中
图(1) / 表(1)
计量
  • 文章访问数:  266
  • HTML全文浏览量:  68
  • PDF下载量:  24
  • 被引次数: 0
出版历程
  • 接收日期:  2022-04-22
  • 网络出版日期:  2022-07-29
  • 刊出日期:  2022-08-31

目录

    /

    返回文章
    返回