全氟和多氟烷基化合物暴露对甲状腺功能影响研究进展

刘晨阳; 王钜铃; 王晓峰; 徐沛维; 金永堂

doi:10.11847/zgggws1138744

全氟和多氟烷基化合物暴露对甲状腺功能影响研究进展

doi: 10.11847/zgggws1138744

刘晨阳^{1, 2},
王钜铃¹,
王晓峰²,
徐沛维²,
金永堂^1, ,

1.
浙江大学公共卫生学院环境表观遗传实验室，杭州 310058
2.
浙江省疾病预防控制中心环境与健康所

详细信息

作者简介:
刘晨阳（1998 – ），男，安徽阜阳人，硕士在读，研究方向：环境污染物暴露毒性

通讯作者:
金永堂，E-mail：jinedu@zju.edu.cn

中图分类号: R 12
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- 被引次数: 0
出版历程
- 接收日期: 2022-04-07
- 网络出版日期: 2023-02-24
- 刊出日期: 2023-05-10

Effects and possible mechanisms of per- and polyfluoroalkyl substances exposure on human thyroid function

1.
Environmental Epigenetics Laboratory, School of Public Health, Zhejiang University, Hangzhou, Zhejiang Province 310058, China

摘要

摘要: 全氟和多氟烷基化合物（per - and polyfluoroalkyl substances，PFASs）是一类人工合成的脂肪族化合物，广泛存在于环境介质中，对人类健康和环境具有潜在、持久性的危害，因此被认为是一种有机污染物（persistent organic pollutants，POPs）。大量实验室及人群流行病学研究表明，暴露于PFASs，不但会引起机体的各种毒性，且可导致甲状腺激素（thyroid hormone，TH）水平的改变，增加发生甲状腺功能减退的风险，进而引起发育迟滞、代谢紊乱等各种相应的临床症状。本文就几种长链、短链及新型PFASs，对PFASs在人体内的毒代动力学过程、PFASs暴露对甲状腺功能的影响及其可能的作用机制作一概述。
- 全氟和多氟烷基化合物 /
- 环境暴露 /
- 甲状腺激素 /
- 甲状腺功能减退
Abstract: Per- and polyfluoroalkyl substances (PFASs) are a class of synthetic aliphatic compounds, which are found widely in environmental media and are potentially and persistently hazardous to human health and the environment, thus being considered as persistent organic pollutants (POPs). Numerous experimental and population - based epidemiological studies have shown that exposure to PFASs not only causes various toxicities in the body, but also leads to changes in thyroid hormone (TH) level and increases the risk of hypothyroidism, which in turn causes various clinical symptoms such as developmental delays and metabolic disorders. In this paper, we describe the toxicokinetic processes of PFASs in humans, based on several long - chain, short - chain and emerging PFASs, and summarize effects and possible mechanisms of PFASs exposure on thyroid function.
- per- and polyfluoroalkyl substances /
- environmental exposure /
- thyroid hormone /
- hypothyroidism

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图 1 PFASs在环境中的分布及在人体内的毒代动力学过程

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图 2 PFASs作用于HPT轴的可能位点

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表 1 几种长链、短链及新型PFASs的基本信息

中文名称	英文名称	简称	类型	CAS号	分子式	相对分子质量
全氟丁酸	perfluorobutanoic acid	PFBA	短链、新型	375-22-4	C₄F₇O₂H	213.9
全氟辛酸	perfluorooctanoic acid	PFOA	长链	335-67-1	C₈F₁₅O₂H	413.93
全氟壬酸	perfluorononanoic acid	PFNA	长链	375-95-1	C₉F₁₇O₂H	464.08
全氟癸酸	perfluorodecanoic acid	PFDA	长链	335-76-2	C₁₀F₁₉O₂H	514.22
全氟十一酸	perfluoroundecanoic acid	PFUdA	长链	2058-94-8	C₁₁F₂₁O₂H	564.1
全氟十二酸	perfluorododecanoic acid	PFDoA	长链	307-55-1	C₁₂F₂₃O₂H	614.11
全氟丁基磺酸	perfluorobutanesulfonic acid	PFBS	短链、新型	375-73-5	C₄F₉SO₃H	299.92
全氟己基磺酸	perfluorohexanesulfonic acid	PFHxS	短链、新型	355-46-4	C₆F₁₃SO₃H	399.97
全氟辛基磺酸	perfluorooctanesulfonic acid	PFOS	长链	1763-23-1	C₈F₁₇SO₃H	499.99

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