Abstract: We established a government cloud platform-based epidemiological survey information management system to improve the capability of response to public health emergencies in Liaoning province. By using big data, cloud computing, image recognition, speech recognition, fifth generation (5G), geographic information systems (GIS) and other technologies, the system takes the advantages of government cloud platform including strong computing power, safe and reliable data exchange, flexible server deployment, and efficient data collection. The system could be used to construct multi-dimensional transmission model of epidemics, to conduct big data analysis, to link the data collected at provincial/municipal and district levels, to assist real-time cross-provincial collaborative investigation, and to carry out closed-loop management on the information of joint prevention and control of epidemic. The established system came into operation in August 2021 in Liaoning province and played an important role in regional epidemic control and prevention.