高级检索

鞍山市2015 — 2018年高血压住院患者药物流行病学特征分析

Antihypertensive regimen among primary hypertension inpatients, 2015 – 2018: an analysis on medical records of three tertiary hospitals in Anshan city

  • 摘要:
    目的 分析辽宁省鞍山市2015 — 2018年高血压住院患者的药物流行病学特征,为进一步评估高血压患者的合理用药提供参考依据。
    方法 于2019年6 — 12月采用分层随机抽样方法通过鞍山市某3家三级甲等医院信息系统随机抽取2015、2016、2017和2018年高血压住院患者的病历资料各300份进行高血压住院患者临床特征及降压药物使用情况的分析。
    结果 鞍山市2015 — 2018年住院治疗的3600例高血压患者中,1级高血压患者525例(14.58%),2级高血压患者1032例(28.67%),3级高血压患者2043例(56.75%);伴发疾病包括左心室肥厚762例(21.17%)、颈动脉硬化301例(8.36%)、冠心病514例(14.28%)、心力衰竭324例(9.00%)、缺血性脑卒中447例(12.42%)、出血性脑卒中269例(7.47%)、慢性肾脏病227例(6.31%);使用降压药物单药治疗者1004例(27.89%),使用联合用药治疗者2596例(72.11%);单药治疗方案中,采用钙离子拮抗剂(CCB)治疗方案的构成比最高(32.37%),其次为采用血管紧张素转化酶抑制剂(ACEI)治疗方案(20.92%);联合用药治疗方案中,采用ACEI/血管紧张素Ⅱ受体拮抗剂(ARB) + CCB + 利尿剂治疗方案的构成比最高(22.65%),其次为采用ACEI/ARB + β – 受体阻滞剂 + CCB治疗方案(22.61%)。
    结论 鞍山市2015 — 2018年高血压住院患者以3级高血压患者居多,多伴发左心室肥厚、冠心病、缺血性脑卒中等疾病,单药治疗以CCB类药物为主,联合用药治疗以ACEI/ARB + CCB + 利尿剂方案为主。

     

    Abstract:
    Objective  To examine antihypertensive regimens among primary hypertension inpatients during 2015 – 2018 in Anshan city of Liaoning province for evaluating rational medication of hypertensive patients.
    Methods  Using stratified random sampling through hospital information systems, we extracted medical records of 3 600 primary hypertension patients hospitalized at three tertiary first-class hospitals during 2015 – 2018 (300 records/per year/per hospital) in Anshan city. The clinical characteristics and antihypertensive regimens of the inpatients were statistically analyzed.
    Results Of all the inpatients, 525 (14.58%), 1032 (28.67%), and 2043 (56.75%) were diagnosed with hypertension of stage I, II, and III, respectively. The proportions of the inpatients having concomitant diseases were 21.17% for left ventricular hypertrophy, 8.36% for carotid atherosclerosis, 14.28% for coronary heart disease, 9.00% for heart failure, 12.42% for ischemic stroke, 7.47% for hemorrhagic stroke, and 6.31% for chronic kidney disease. Among all the inpatients during the hospitalizations, 1 004 (27.89%) had single antihypertensive medication and 2 596 (72.11%) had combined antihypertensive medication. Among the monotherapy regimens, calciumion antagonists (CCB) was the most frequently used drug in 325 (32.37%)of the inpatients, followed by angiotensin converting enzyme inhibitors (ACEI) in 210 (20.92%) of the inpatients. Of the inpatients with the combined regimens, 588 (22.65%) had the medication of ACEI/angiotensin receptor blocker (ARB) plus CCB plus diuretic and 587 (22.61%) had the medication of ACEI/ARB plus β-receptor blocker plus CCB. The antihypertensive regimens differed significantly by hypertension stage among the inpatients (χ2 = 1 922.86, P < 0.001).
    Conclusion For the primary hypertensive patients hospitalized during 2015 – 2018 in Anshan city, more than a half had stage III hypertension and left ventricular hypertrophy, coronary artery disease, and ischemic stroke were major concomitant diseases; CCB was a main monotherapy and ACEI/ARB plus CCB plus diuretic was a main combined antihypertensive regimen in the treatment of the inpatients during hospitalization.

     

/

返回文章
返回