细胞外囊泡在吸烟所致慢性阻塞性肺病中作用及其机制研究进展

陆璐; 施爱民; 刘起展

doi:10.11847/zgggws1139677

细胞外囊泡在吸烟所致慢性阻塞性肺病中作用及其机制研究进展

doi: 10.11847/zgggws1139677

陆璐¹,
施爱民^{1, 2},
刘起展^2, ,

1.
南京医科大学医药实验动物中心江苏省医药动物实验基地，江苏南京 211166
2.
南京医科大学公共卫生学院现代毒理教育部重点实验室

基金项目: 国家自然科学基金（82173563；81973085）

详细信息

作者简介:
陆璐（1991 – ），女，江苏扬州人，实验师，硕士，研究方向：环境毒理

通讯作者:
刘起展，E-mail：qzliu@njmu.edu.cn

中图分类号: R 114
计量
- 文章访问数: 40
- HTML全文浏览量: 22
- PDF下载量: 14
- 被引次数: 0
出版历程
- 收稿日期: 2022-07-07
- 网络出版日期: 2023-01-10

Role and mechanism of extracellular vesicles in smoking-induced chronic obstructive pulmonary disease: a review on research progress

LU Lu¹,
SHI Ai-min^{1, 2},
LIU Qi-zhan^{2
, ,}

1.
Jiangsu Animal Experimental Center of Medical and Pharmaceutical Research, Animal Core Facility, Nanjing Medical University, Nanjing, Jiangsu Province 211166, China

摘要

摘要: 慢性阻塞性肺病（chronic obstructive pulmonary disease, COPD）是一种复杂的异质性呼吸系统疾病，其主要是因长期吸入有害颗粒引起的肺功能和肺结构的改变。香烟烟雾（cigarette smoke, CS）是COPD的主要危险因素，其引起的炎症、细胞应激和组织破坏在COPD中发挥关键作用。细胞外囊泡（extracellular vesicles, EVs）为一种具有功能活性的纳米级膜结合囊泡，近年来因其在许多疾病诊断和治疗中发挥重要作用而受到越来越多的关注，但其在吸烟所致COPD中的作用及其机制的研究仍处于起步阶段，为此本文对EVs在CS所致COPD中的作用及其机制的国内外研究作一概述。
- 细胞外囊泡 /
- 吸烟 /
- 香烟烟雾 /
- 慢性阻塞性肺病
Abstract: Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous respiratory disease that is characterized by functional and structural alterations mainly caused by long - term inhalation of harmful particles. Cigarette smoke (CS) is a major risk factor for COPD. Inflammation, cellular stress, and tissue damage caused by cigarette smoke play key roles in COPD progression. Extracellular vesicles (EVs) are functional nanoscale membrane - bound vesicles. Recently, EVs have attracted more and more attention due to their roles in the diagnosis and treatment of many diseases. However, the research on the roles and mechanism of EVs in smoking - induced COPD is still in its infancy. In this paper, we provided an overview of national and international research on the roles and mechanisms of EVs in the pathogenesis of CS - induced COPD.
- extracellular vesicles /
- smoking /
- cigarette smoke /
- chronic obstructive pulmonary disease

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参考文献(41)

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