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深圳市南山区2021 — 2022年流感流行季中小学生接种流感疫苗效果评价

姜世强 彭铭记 蔡羽薇 彭质斌 袁建辉

姜世强, 彭铭记, 蔡羽薇, 彭质斌, 袁建辉. 深圳市南山区2021 — 2022年流感流行季中小学生接种流感疫苗效果评价[J]. 中国公共卫生, 2023, 39(7): 848-850. doi: 10.11847/zgggws1140344
引用本文: 姜世强, 彭铭记, 蔡羽薇, 彭质斌, 袁建辉. 深圳市南山区2021 — 2022年流感流行季中小学生接种流感疫苗效果评价[J]. 中国公共卫生, 2023, 39(7): 848-850. doi: 10.11847/zgggws1140344
JIANG Shiqiang, PENG Mingji, CAI Yuwei, PENG Zhibin, YUAN Jianhui. Influenza vaccine effectiveness in primary and secondary school students: an ILI surveillance-based test-negative design case-control study in a district of Shenzhen city during 2021 – 2022 influenza season[J]. Chinese Journal of Public Health, 2023, 39(7): 848-850. doi: 10.11847/zgggws1140344
Citation: JIANG Shiqiang, PENG Mingji, CAI Yuwei, PENG Zhibin, YUAN Jianhui. Influenza vaccine effectiveness in primary and secondary school students: an ILI surveillance-based test-negative design case-control study in a district of Shenzhen city during 2021 – 2022 influenza season[J]. Chinese Journal of Public Health, 2023, 39(7): 848-850. doi: 10.11847/zgggws1140344

深圳市南山区2021 — 2022年流感流行季中小学生接种流感疫苗效果评价

doi: 10.11847/zgggws1140344
基金项目: 广东省医学科学技术研究基金(B2022268);南山区区域学科联盟(20200918)
详细信息
    作者简介:

    姜世强(1980 – ),副主任医师,硕士,研究方向:免疫规划管理研究

    通信作者:

    袁建辉,E-mail:sncdcyjh@szns.gov.cn

  • 中图分类号: R 186

Influenza vaccine effectiveness in primary and secondary school students: an ILI surveillance-based test-negative design case-control study in a district of Shenzhen city during 2021 – 2022 influenza season

More Information
  • 摘要:   目的  采用检测阴性设计(TND)病例对照研究评价中小学生接种灭活三价流感疫苗的保护效果(VE)。  方法  对深圳市南山区2021年11月 — 2022年5月综合医院发热门诊发现的286例6~15岁中小学生流感样病例(ILI)进行流感病毒核酸PCR检测,流感病毒核酸检测阳性者为阳性病例组,检测阴性者为阴性对照组,收集2组的流感疫苗接种记录,计算2组的流感疫苗接种比值比(OR)及VE。  结果  286例ILI中,流感病毒核酸检测阳性68例(23.78%),均为乙型流感,阴性218例(76.22%),病例组当季流感疫苗接种率为5.88%(4/68),对照组接种率为15.14%(33/218),OR值为0.3886(95%CI = 0.1528~0.9880),VE为61.14%(95%CI = 1.20%~84.72%)。  结论  接种当季流感疫苗可以保护中小学生感染流感,鼓励中小学生接种当季流感疫苗以预防流感。
  • 表  1  2021 — 2022年流感流行季南山区中小学ILI病例基本特征比较

    Table  1.   Gender, age and vaccination status by flu virus nucleic acid test for 286 child ILI cases during 2021 – 2022 flu season in a district of Shenzhen city

    项目病例组(n = 68)对照组(n = 218)χ2 P
    例数%例数%
    性别
     男生4566.1815269.720.3040.581
     女生2333.826630.28
    年龄(岁)
      6~6291.1818183.302.6940.101
     12~1568.823716.97
    上季流感疫苗接种情况
     是3652.9412456.880.3260.568
     否3247.069443.12
    下载: 导出CSV

    表  2  2021 — 2022年流感流行季南山区中小学生当季流感疫苗效果评价

    Table  2.   Influenza vaccine efficacy estimation based on flu virus nucleic acid detection among 286 child ILI cases during 2021 – 2022 flu season in a district of Shenzhen city

    当季流感疫苗接种病例组对照组OR 95%CIVE(%)95%CI(%)
    例数%例数%
    接种45.883315.140.38860.1528~0.988061.141.2~84.72
    未接种6494.1218584.86
    合计68100.00218100.00
    下载: 导出CSV
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出版历程
  • 接收日期:  2022-09-16
  • 录用日期:  2023-03-10
  • 修回日期:  2023-01-03
  • 网络出版日期:  2023-03-17
  • 刊出日期:  2023-07-10

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