BMI heritability and its relationship with puberty in 6 – 18-year-old twins
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摘要:
目的 分析山东省6~18岁双生子BMI的遗传度及青春期影响。 方法 于2021年11月通过山东省3县区453对6~18岁同性别双生子构建结构方程模型计算BMI遗传度,探究青春期对BMI遗传度的影响及性别差异。 结果 调整性别、年龄后6~18岁儿童青少年BMI的遗传度为0.84(95%CI = 0.80~0.88),青春期前期BMI的遗传度为0.81(95%CI = 0.74~0.86),青春期后期BMI的遗传度为0.88(95%CI = 0.81~0.93);男生和女生青春期前期BMI遗传度分别为0.77(95%CI = 0.67~0.85)和0.85(95%CI = 0.77~0.91),青春期后期分别为0.92(95%CI = 0.82~0.97)和0.86(95%CI = 0.76~0.92)。 结论 遗传因素对青春期前后BMI变异具有重要影响,BMI的遗传度在青春期后期增加,且在男生中更为明显。 Abstract:Objective To analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province. Methods Data on 453 pairs of child and adolescent twins of the same sex were collected from three counties/districts of Shandong province in November 2021. Univariate structural equation modeling was used to estimate the heritability of BMI. Results After adjusting for gender and age, the heritability of BMI in the twins was 0.88 (95% confidence interval [95%CI]: 0.80 – 0.88); the heritability of prepubertal BMI was 0.81 (95%CI: 0.74 – 0.86); and the heritability of BMI in late puberty was 0.88 (95%CI: 0.81 – 0.93). The heritability of BMI in prepubertal boys and girls was 0.77 (95%CI: 0.67 – 0.85) and 0.85 (95%CI: 0.77 – 0.91), and 0.92 (95%CI: 0.82 – 0.97) and 0.86 (95%CI: 0.76 – 0.92) in late puberty, respectively. Conclusion Genetic factors appear to play an important role in explaining the variation of BMI from prepuberty to late puberty, particularly in boys. -
Key words:
- body mass index /
- twin study /
- heritability /
- puberty
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表 1 不同性别与青春期分期对象的卵型分布情况
特征 MZ DZ χ2 值 P 值 对数 % 对数 % 性别 0.01 0.939 男生 123 47.31 92 47.67 女生 137 52.69 101 52.33 青春分期 2.84 0.092 前期 175 67.31 144 74.61 后期 85 32.69 49 25.39 表 2 青春期前后BMI的对内相关性系数(r)及其95%CI
组别 青春期前 青春期后 全体 r 95%CI r 95%CI r 95%CI 男生 MZ 0.82 0.69~0.91 0.91 0.70~0.97 0.85 0.74~0.92 DZ 0.45 0.24~0.63 0.18 – 0.37~0.73 0.46 0.29~0.62 女生 MZ 0.87 0.80~0.93 0.88 0.80~0.93 0.91 0.87~0.94 DZ 0.46 0.20~0.67 0.45 0.09~0.76 0.60 0.46~0.74 全体 MZ 0.85 0.76~0.90 0.89 0.83~0.93 0.88 0.83~0.92 DZ 0.51 0.35~0.63 0.35 0.07~0.64 0.55 0.44~0.66 表 3 青春期前后BMI的遗传和环境效应系数及95%CI
组别 模型I 模型II 青春期前 青春期后 全体 青春期前 青春期后 全体 系数 95%CI 系数 95%CI 系数 95%CI 系数 95%CI 系数 95%CI 系数 95%CI 男生 A 0.80 0.70~0.87 0.92 0.82~0.97 0.84 0.77~0.89 0.77 0.67~0.85 0.92 0.82~0.97 0.81 0.73~0.87 E 0.20 0.13~0.30 0.08 0.03~0.18 0.16 0.11~0.33 0.23 0.15~0.33 0.08 0.03~0.18 0.19 0.13~0.27 女生 A 0.86 0.79~0.91 0.87 0.77~0.92 0.90 0.85~0.93 0.85 0.77~0.91 0.86 0.76~0.92 0.86 0.80~0.90 E 0.14 0.09~0.21 0.13 0.08~0.23 0.10 0.07~0.15 0.15 0.09~0.23 0.14 0.08~0.24 0.14 0.10~0.20 全体 A 0.84 0.78~0.88 0.88 0.81~0.93 0.87 0.84~0.90 0.81 0.74~0.86 0.88 0.81~0.93 0.84 0.80~0.88 E 0.16 0.12~0.22 0.12 0.07~0.19 0.13 0.10~0.16 0.19 0.14~0.26 0.12 0.07~0.19 0.16 0.12~0.20 注:模型I表示调整性别和年龄前;模型II表示调整性别和年龄后;A表示加性遗传方差;E表示特殊环境方差。 -
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