6～18岁双生子BMI遗传度及与青春期关系

郭婷婷; 白云洁; 樊爱平; 范丽丽; 李元成; 陈天娇

doi:10.11847/zgggws1140774

6～18岁双生子BMI遗传度及与青春期关系

doi: 10.11847/zgggws1140774

1.
北京大学公共卫生学院儿童青少年卫生研究所，北京 100191
2.
泰山区疾病预防控制中心
3.
泰安市疾病预防控制中心
4.
肥城市疾病预防控制中心
5.
山东第一医科大学公共卫生学院

基金项目: 国家自然科学基金（81001249）

详细信息

作者简介:
郭婷婷（1997 – ），女，山东济宁人，硕士在读，研究方向：儿童生长发育及影响因素

通讯作者:
陈天娇，E-mail：tianjiao.chen@hsc.pku.edu.cn

中图分类号: R 179
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- 被引次数: 0
出版历程
- 接收日期: 2022-11-07
- 网络出版日期: 2023-02-24
- 刊出日期: 2023-05-10

BMI heritability and its relationship with puberty in 6 – 18-year-old twins

1.
Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100191 China

摘要

摘要: 目的分析山东省6～18岁双生子BMI的遗传度及青春期影响。方法于2021年11月通过山东省3县区453对6～18岁同性别双生子构建结构方程模型计算BMI遗传度，探究青春期对BMI遗传度的影响及性别差异。结果调整性别、年龄后6～18岁儿童青少年BMI的遗传度为0.84（95%CI = 0.80～0.88），青春期前期BMI的遗传度为0.81（95%CI = 0.74～0.86），青春期后期BMI的遗传度为0.88（95%CI = 0.81～0.93）；男生和女生青春期前期BMI遗传度分别为0.77（95%CI = 0.67～0.85）和0.85（95%CI = 0.77～0.91），青春期后期分别为0.92（95%CI = 0.82～0.97）和0.86（95%CI = 0.76～0.92）。结论遗传因素对青春期前后BMI变异具有重要影响，BMI的遗传度在青春期后期增加，且在男生中更为明显。
- 体质指数 /
- 双生子研究 /
- 遗传度 /
- 青春期
Abstract: Objective To analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province. Methods Data on 453 pairs of child and adolescent twins of the same sex were collected from three counties/districts of Shandong province in November 2021. Univariate structural equation modeling was used to estimate the heritability of BMI. Results After adjusting for gender and age, the heritability of BMI in the twins was 0.88 (95% confidence interval [95%CI]: 0.80 – 0.88); the heritability of prepubertal BMI was 0.81 (95%CI: 0.74 – 0.86); and the heritability of BMI in late puberty was 0.88 (95%CI: 0.81 – 0.93). The heritability of BMI in prepubertal boys and girls was 0.77 (95%CI: 0.67 – 0.85) and 0.85 (95%CI: 0.77 – 0.91), and 0.92 (95%CI: 0.82 – 0.97) and 0.86 (95%CI: 0.76 – 0.92) in late puberty, respectively. Conclusion Genetic factors appear to play an important role in explaining the variation of BMI from prepuberty to late puberty, particularly in boys.
- body mass index /
- twin study /
- heritability /
- puberty

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表 1 不同性别与青春期分期对象的卵型分布情况

特征	MZ		DZ		χ² 值	P 值
特征	对数	%	对数	%	χ² 值	P 值
性别					0.01	0.939
男生	123	47.31	92	47.67
女生	137	52.69	101	52.33
青春分期					2.84	0.092
前期	175	67.31	144	74.61
后期	85	32.69	49	25.39

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表 2 青春期前后BMI的对内相关性系数（r）及其95%CI

组别		青春期前		青春期后		全体
组别		r	95%CI	r	95%CI	r	95%CI
男生	MZ	0.82	0.69～0.91	0.91	0.70～0.97	0.85	0.74～0.92
	DZ	0.45	0.24～0.63	0.18	– 0.37～0.73	0.46	0.29～0.62
女生	MZ	0.87	0.80～0.93	0.88	0.80～0.93	0.91	0.87～0.94
	DZ	0.46	0.20～0.67	0.45	0.09～0.76	0.60	0.46～0.74
全体	MZ	0.85	0.76～0.90	0.89	0.83～0.93	0.88	0.83～0.92
	DZ	0.51	0.35～0.63	0.35	0.07～0.64	0.55	0.44～0.66

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表 3 青春期前后BMI的遗传和环境效应系数及95%CI

组别		模型I						模型II
		青春期前		青春期后		全体		青春期前		青春期后		全体
		系数	95%CI	系数	95%CI	系数	95%CI	系数	95%CI	系数	95%CI	系数	95%CI
男生	A	0.80	0.70～0.87	0.92	0.82～0.97	0.84	0.77～0.89	0.77	0.67～0.85	0.92	0.82～0.97	0.81	0.73～0.87
	E	0.20	0.13～0.30	0.08	0.03～0.18	0.16	0.11～0.33	0.23	0.15～0.33	0.08	0.03～0.18	0.19	0.13～0.27
女生	A	0.86	0.79～0.91	0.87	0.77～0.92	0.90	0.85～0.93	0.85	0.77～0.91	0.86	0.76～0.92	0.86	0.80～0.90
	E	0.14	0.09～0.21	0.13	0.08～0.23	0.10	0.07～0.15	0.15	0.09～0.23	0.14	0.08～0.24	0.14	0.10～0.20
全体	A	0.84	0.78～0.88	0.88	0.81～0.93	0.87	0.84～0.90	0.81	0.74～0.86	0.88	0.81～0.93	0.84	0.80～0.88
	E	0.16	0.12～0.22	0.12	0.07～0.19	0.13	0.10～0.16	0.19	0.14～0.26	0.12	0.07～0.19	0.16	0.12～0.20
注：模型I表示调整性别和年龄前；模型II表示调整性别和年龄后；A表示加性遗传方差；E表示特殊环境方差。

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