苏州市9～15岁女生母亲HPV疫苗免费供应方案选择意愿调查

王天宇; 邓景景; 栾琳; 徐娟; 郑本锋; 龚甜; 张琢玉; 张钧

doi:10.11847/zgggws1140930

苏州市9～15岁女生母亲HPV疫苗免费供应方案选择意愿调查

doi: 10.11847/zgggws1140930

王天宇¹,
邓景景²,
栾琳^{1, 2, ,},
徐娟²,
郑本锋²,
龚甜³,
张琢玉¹,
张钧^{1, 2, ,}

1.
南京医科大学公共卫生学院，南京 211166
2.
苏州市疾病预防控制中心，苏州 215004
3.
苏州市妇幼保健计划生育服务中心，苏州 215301

基金项目: 苏州市姑苏卫生人才计划（GSWS2021055）

详细信息

作者简介:
王天宇（1998 – ），女，江苏南通人，硕士在读，研究方向：疾病控制

通讯作者:
栾琳，E-mail：szluanlin@163.com

张钧，E-mail：sz_zhangj@163.com

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- 被引次数: 0
出版历程
- 接收日期: 2022-11-24
- 录用日期: 2023-04-03
- 修回日期: 2023-03-22
- 网络出版日期: 2023-05-15

Intention choice of daughters′ free HPV vaccination scheme: an online survey among mothers of school-age girls in Suzhou city

WANG Tianyu¹,
DENG Jingjing²,
LUAN Lin^{1, 2
, ,},
XU Juan²,
ZHENG Benfeng²,
GONG Tian³,
ZHANG Zhuoyu¹,
ZHANG Jun^{1, 2
, ,}

1.
School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
Suzhou Municipal Center for Disease Control and Prevention, Suzhou 215004, China
3.
Suzhou City Maternal and Child Health and Family Planning Service Center，Suzhou 215301, China

More Information

Corresponding author: LUAN Lin, E-mail：szluanlin@163.com; ZHANG Jun, E-mail：sz_zhangj@163.com

摘要

摘要: 目的对适龄9～15岁女生母亲的宫颈癌知识、人乳头瘤病毒（HPV）疫苗知识和对不同HPV疫苗免费供应方案的选择意愿进行调查，为卫生行政部门制定相关免疫接种策略提供依据。方法于2022年10月通过“苏州预防接种”官方微信公众服务号向苏州市9～15岁女生母亲推送自行设计的问卷进行在线网络调查。结果共1648人参与调查，回收有效问卷1484份。如果政府开展适龄女生双价HPV疫苗免费接种项目，4种HPV疫苗免费供应方案选择人数由多至少依次为：699人（47.10%）选择方案二（免费接种中标国产双价HPV疫苗或自费补差价接种其他疫苗的方案）、565人（38.07%）选择方案一（采用参照二针国产双价HPV疫苗价格的现金补贴方案）、161人（10.85%）选择方案三（免费接种中标国产双价HPV疫苗或全自费接种其他疫苗的方案）和59人（3.98%）选择方案四（保证供应但纯自费接种方案）。不同学历（χ² = 53.77，P < 0.05）、家庭月收入（χ² = 49.07，P < 0.05）和认知得分（χ² = 8.19，P = 0.04）对HPV疫苗免费供应方案的选择差异有统计学意义。多元logistics回归模型结果显示，相较于方案四，家庭月收入 ≤5000元是选择方案一（OR = 5.65）、方案二（OR = 5.31）和方案三（OR = 14.34）的影响因素；选择方案一的影响因素还有家庭月收入10001～15000元（OR = 2.59）；方案三的影响因素还有月收入5001～10000元（OR = 2.60）。在4种方案中选择接种九价疫苗的人均占比最多，分别为94.16%（532/565）、83.26%（582/699）、55.28%（89/161）和98.31%（58/59）。结论苏州市9～15岁女生母亲选择方案二的人数最多，家庭月收入和学历是HPV疫苗免费供应方案选择的影响因素。所有接种方案中家长对九价疫苗的选择最多，应尽快推进国产高性价比的九价HPV疫苗的研发、生产与供应。
- 9～15岁女生 /
- HPV疫苗 /
- 免费供应方案 /
- 苏州
Abstract: Objective To investigate the knowledge on cervical cancer and human papillomavirus (HPV) vaccine, and intention choice of daughters′ free HPV vaccination scheme among mothers of school-age girls for providing evidence to administrative departments in developing relevant vaccination strategies. Methods Using convenient sampling and a self-designed questionnaire, we conducted an online survey among 1 648 mothers of girls aged 9 – 15 years through official WeChat website of Suzhou Vaccination during October 2022. The data collected from 1 484 eligible respondents were statistically analyzed. Results Of the 1 484 respondents for the four listed HPV vaccination schemes available to their daughters (including free domestic bivalent or subsidized HPV vaccine supplied by health administrative departments), 699 (47.10%) selected plan 2 (free domestic bivalent HPV vaccine or partially subsidized vaccination of other HPV vaccines); 565 (38.07%) selected plan 1 (with cash subsidy for other HPV vaccination according to the price of two-dose vaccination of domestic bivalent HPV vaccine); 161 (10.85%) selected plan 3 (free vaccination of domestic HPV vaccine or self-paid vaccination of other HPV vaccines); and 59 (3.98%) selected plan 4 (self-paid vaccination of all other HPV vaccines available). Nine-valent HPV vaccine was the most frequently selected vaccine reported by the four groups of respondents with different intention choice of the vaccination scheme, with the selecting ratios of 94.16%, 83.26%, 55.28%, and 98.31% for the respondents reporting the intention choice of vaccination plan 2, 1, 3, and 4, respectively. The respondents' intention choice of daughters′ free HPV vaccination scheme differed significantly by educational background (χ² = 53.77, P < 0.05), monthly household income (χ² = 49.07, P < 0.05), and the score of cognition on cervical cancer and HPV vaccine (χ² = 8.19, P = 0.04). The results of multivariate logistic regression model showed that compared to those with a monthly household income of ≥ 20 001 (Chinese Yuan), the respondents with a monthly household income of ≤ 5 000 were more likely to select the plan 1 (odds ratio [OR] = 5.65), plan 2 (OR = 5.31), and plan 3 (OR = 14.34) other than the plan 4; the respondents with a monthly household income of 10 001 – 15 000 were likely to select the plan 3 (OR = 2.59) other than the plan 4; and the respondents with a monthly family income of 5 001 – 10 000 were more likely to select the plan 3 (OR = 2.60) other than the plan 4. Conclusion In Suzhou city, about one half of the mothers of school-age girls intend to select free domestic bivalent vaccine or partially subsidized vaccination of other vaccines for their daughters′ free HPV vaccination scheme, with nine-valent HPV vaccine being the most frequently selected vaccine, and the intention choice is mainly influenced by maternal monthly household income and education background.
- girls aged 9-15 years /
- human papilloma virus vaccine /
- free vaccination scheme /
- Suzhou city

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表 1 苏州市9～15岁女生母亲对HPV疫苗免费供应方案选择的单因素分析

Table 1. Age-, education-, household income-, and relevant knowledge-specific intention choice of free HPV vaccination scheme among 1 484 mothers of girls aged 9 – 15 years in Suzhou city

项目	方案一（n = 565）		方案二（n = 699）		方案三（n = 161）		方案四（n = 59）		χ² 值	P 值
项目	人数	构成比（%）	人数	构成比（%）	人数	构成比（%）	人数	构成比（%）	χ² 值	P 值
年龄（岁）									8.60	0.20
≤ 35	157	27.79	214	30.61	63	39.13	15	25.42
36～40	277	49.03	326	46.64	64	39.75	29	49.15
≥ 41	131	23.18	159	22.75	34	21.12	15	25.42
学历									53.77	< 0.01
中专/高中及以下	109	19.29	177	25.32	71	44.10	15	25.42
大专	173	30.62	230	32.90	43	26.71	11	18.64
本科	256	45.31	259	37.05	45	27.95	28	47.46
研究生及以上	27	4.78	33	4.72	2	1.24	5	8.47
家庭月收入（元）									49.07	< 0.01
≤ 5000	50	8.85	71	10.16	37	22.98	2	3.39
5001～10000	154	27.26	220	31.47	56	34.78	17	28.81
10001～15000	140	24.78	154	22.03	28	17.39	9	15.25
15001～20000	109	19.29	120	17.17	23	14.29	12	20.34
≥ 20001	112	19.82	134	19.17	17	10.56	19	32.20
认知得分
低分组	135	23.89	193	27.61	56	34.78	18	30.51	8.19	0.04
高分组	430	76.11	506	72.39	105	65.22	41	69.49
注：方案一，采用参照二针国产双价HPV疫苗价格（约600元）的现金补贴方案；方案二，免费接种中标国产双价HPV疫苗或自费补差价接种其他疫苗的方案；方案三，免费接种中标国产双价HPV疫苗或全自费接种其他疫苗的方案；方案四，采用保证供应但纯自费接种方案。

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表 2 苏州市9～15岁女生母亲对HPV疫苗免费供应方案选择意愿多因素分析

Table 2. Education-, household income-, and relevant knowledge-specific intention choice of free HPV vaccination scheme among 1 484 mothers of girls aged 9 – 15 years in Suzhou city: multivariate analysis

项目	对照组	方案一			方案二			方案三
项目	对照组	OR 值	P 值	95%CI	OR 值	P 值	95%CI	OR 值	P 值	95%CI
学历
中专/高中及以下	研究生及以上	0.93	0.90	0.28～3.07	1.19	0.77	0.37～3.87	5.26	0.07	0.86～32.39
大专		2.27	0.18	0.69～7.41	2.46	0.13	0.76～7.90	6.03	0.05	0.98～37.00
本科		1.47	0.47	0.52～4.20	1.23	0.70	0.44～3.44	3.10	0.20	0.55～17.34
家庭月收入（元）
≤ 5000	≥ 20001	5.65	0.03	1.18～27.11	5.31	0.04	1.12～25.21	14.34	0.00	2.76～74.49
5001～10000		1.68	0.19	0.77～3.64	1.71	0.17	0.79～3.69	2.60	0.04	1.03～6.59
10001～15000		2.59	0.03	1.10～6.13	2.17	0.08	0.92～5.09	2.64	0.06	0.94～7.38
15001～20000		1.48	0.33	0.68～3.22	1.32	0.49	0.61～2.85	1.83	0.22	0.70～4.82
认知得分
低分组	高分组	0.67	0.19	0.36～1.23	0.73	0.31	0.40～1.34	0.80	0.51	0.41～1.57
注：方案一，采用参照二针国产双价HPV疫苗价格（约600元）的现金补贴方案；方案二，免费接种中标国产双价HPV疫苗或自费补差价接种其他疫苗的方案；方案三，免费接种中标国产双价HPV疫苗或全自费接种其他疫苗的方案。

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表 3 苏州市9～15岁女生母亲在免费供应方案中选择HPV疫苗类型情况

Table 3. Intention choice of HPV vaccine type by free HPV vaccination scheme among 1 484 mothers of girls aged 9 – 15 years in Suzhou city

HPV疫苗	HPV疫苗免费供应方案
	方案一		方案二		方案三		方案四
	人数	构成比（%）	人数	构成比（%）	人数	构成比（%）	人数	构成比（%）
国产二价疫苗	7	1.24	59	8.44	53	32.92	0	0.00
进口二价疫苗	11	1.95	26	3.72	8	4.97	0	0.00
四价疫苗	15	2.65	31	4.43	10	6.21	1	1.69
九价疫苗	532	94.16	582	83.26	89	55.28	58	98.31
不接种疫苗	0	0.00	1	0.14	1	0.62	0	0.00
注：方案一，采用参照二针国产双价HPV疫苗价格（约600元）的现金补贴方案；方案二，免费接种中标国产双价HPV疫苗或自费补差价接种其他疫苗的方案；方案三，免费接种中标国产双价HPV疫苗或全自费接种其他疫苗的方案；方案四，采用保证供应但纯自费接种方案。

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