老年衰弱生物标志物研究进展

杨锦竹; 何凌骁; 方亚

doi:10.11847/zgggws1141132

老年衰弱生物标志物研究进展

doi: 10.11847/zgggws1141132

厦门大学公共卫生学院卫生技术评估福建省高校重点实验室，厦门 361102

基金项目: 国家自然科学基金（81973144）

详细信息

作者简介:
杨锦竹（1998 – ），硕士在读，研究方向：健康老龄化

通信作者:
方亚，E-mail：fangya@xmu.edu.cn

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- 文章访问数: 119
- HTML全文浏览量: 51
- PDF下载量: 23
- 被引次数: 0
出版历程
- 接收日期: 2022-02-20
- 录用日期: 2023-05-24
- 修回日期: 2023-04-03
- 网络出版日期: 2023-09-06
- 刊出日期: 2023-08-10

A review on progress in research on biomarkers of frailty in elderly

Key Laboratory of Health Technology Assessment of Fujian Province, School of Public Health, Xiamen University, Xiamen 361102, China

More Information

Corresponding author: FANG Ya, E-mail：fangya@xmu.edu.cn

摘要

摘要: 衰弱是一种老年人群中常见的、以机体稳态储备能力下降及抗应激能力减退为特征的临床状态，在我国有较高的年发生率且与诸多不良结局相关，给家庭和社会带来沉重负担。因此，对老年衰弱的监测及早期诊断将有助于早期干预措施的实施，从而达到延缓或逆转衰弱的发生，维持老年健康的目的。鉴于衰弱是机体多组织器官功能衰退综合作用的结果，与机体功能水平相关的生物因子或可为衰弱的监测提供新思路。因此，本文将从代谢、免疫、氧化应激、炎症、营养等方面介绍与衰弱相关的生物标志物，以期为衰弱的监测与早期诊断提供更多的生物学依据。
- 衰弱 /
- 生物标志物 /
- 老年人
Abstract: Frailty is a common clinical condition in older adults, which is characterized by decreased steady-state reserve capacity and anti-stress ability. The incidence of frailty is high in China and is associated with many adverse outcomes, bringing heavy burden to the family and society. Therefore, frailty monitoring and early detection will contribute to the implementation of relevant interventions and to delay the onset of frailty or even reverse frailty status and finally to a good maintenance in health condition. Since frailty is the result of multi-organ functional declines, evaluations on biological factors related to body function may provide a new solution for frailty monitoring. In this paper, we summarize the research on frailty-related biomarkers of metabolism, immunity, oxidative stress, inflammation and nutrition for providing a reference to monitoring and early diagnosis of frailty.
- frailty /
- biomarker /
- the elderly

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参考文献(45)

[1]	Clegg A, Young J, Iliffe S, et al. Frailty in elderly people[J]. Lancet, 2013, 381(9868): 752 – 762. doi: 10.1016/S0140-6736(12)62167-9
[2]	Collard RM, Boter H, Schoevers RA, et al. Prevalence of frailty in community-dwelling older persons: a systematic review[J]. J Am Geriatr Soc, 2012, 60(8): 1487 – 1492. doi: 10.1111/j.1532-5415.2012.04054.x
[3]	McAdams-DeMarco M, Chu NM, Segev DL. Differences between cystatin C- and creatinine-based estimated GFR-early evidence of a clinical marker for frailty[J]. Am J Kidney Dis, 2020, 76(6): 752 – 753. doi: 10.1053/j.ajkd.2020.07.010
[4]	Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people[J]. J Gerontol A Biol Sci Med Sci, 2007, 62(7): 738 – 743. doi: 10.1093/gerona/62.7.738
[5]	Chew J, Tay L, Lim JP, et al. Serum myostatin and IGF-1 as gender-specific biomarkers of frailty and low muscle mass in community-dwelling older adults[J]. J Nutr Health Aging, 2019, 23(10): 979 – 986. doi: 10.1007/s12603-019-1255-1
[6]	Peng LN, Lee WJ, Liu LK, et al. Healthy community-living older men differ from women in associations between myostatin levels and skeletal muscle mass[J]. J Cachexia Sarcopenia Muscle, 2018, 9(4): 635 – 642. doi: 10.1002/jcsm.12302
[7]	Spira D, Buchmann N, König M, et al. Sex-specific differences in the association of vitamin D with low lean mass and frailty: results from the Berlin aging study II[J]. Nutrition, 2019, 62: 1 – 6. doi: 10.1016/j.nut.2018.11.020
[8]	Sousa-Santos AR, Afonso C, Santos A, et al. The association between 25(OH)D levels, frailty status and obesity indices in older adults[J]. PLoS One, 2018, 13(8): e0198650. doi: 10.1371/journal.pone.0198650
[9]	Doi T, Makizako H, Tsutsumimoto K, et al. Association between insulin-like growth factor-1 and frailty among older adults[J]. J Nutr Health Aging, 2018, 22(1): 68 – 72. doi: 10.1007/s12603-017-0916-1
[10]	Lana A, Valdés-Bécares A, Buño A, et al. Serum leptin concentration is associated with incident frailty in older adults[J]. Aging Dis, 2017, 8(2): 240 – 249. doi: 10.14336/AD.2016.0819
[11]	Muratsu J, Kamide K, Fujimoto T, et al. The combination of high levels of adiponectin and insulin resistance are affected by aging in non-obese old peoples[J]. Front Endocrinol (Lausanne), 2022, 12: 805244. doi: 10.3389/fendo.2021.805244
[12]	de Almeida Holanda CM, Guerra RO, de Negreiros Nóbrega PV, et al. Salivary cortisol and frailty syndrome in elderly residents of long-stay institutions: a cross-sectional study[J]. Arch Gerontol Geriatr, 2012, 54(2): e146 – e151. doi: 10.1016/j.archger.2011.11.006
[13]	Bano A, Chaker L, Schoufour J, et al. High circulating free thyroxine levels may increase the risk of frailty: the rotterdam study[J]. J Clin Endocrinol Metab, 2018, 103(1): 328 – 335. doi: 10.1210/jc.2017-01854
[14]	Furtado GE, Carvalho HM, Loureiro M, et al. Chair-based exercise programs in institutionalized older women: salivary steroid hormones, disabilities and frailty changes[J]. Exp Gerontol, 2020, 130: 110790. doi: 10.1016/j.exger.2019.110790
[15]	Zampino M, Ferrucci L, Semba RD. Biomarkers in the path from cellular senescence to frailty[J]. Exp Gerontol, 2020, 129: 110750. doi: 10.1016/j.exger.2019.110750
[16]	Mailliez A, Guilbaud A, Puisieux F, et al. Circulating biomarkers characterizing physical frailty: CRP, hemoglobin, albumin, 25OHD and free testosterone as best biomarkers. Results of a meta-analysis[J]. Exp Gerontol, 2020, 139: 111014. doi: 10.1016/j.exger.2020.111014
[17]	Lu YX, Tan CTY, Nyunt MSZ, et al. Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies[J]. Oncotarget, 2016, 7(20): 28783 – 28795. doi: 10.18632/oncotarget.8939
[18]	Zhang H, Hao M, Hu ZX, et al. Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study[J]. Immun Ageing, 2022, 19(1): 1. doi: 10.1186/s12979-021-00257-6
[19]	Samson LD, Boots AMH, Verschuren WMM, et al. Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes[J]. Exp Gerontol, 2019, 125: 110674. doi: 10.1016/j.exger.2019.110674
[20]	Núñez J, Sastre C, D'Ascoli G, et al. Relation of low lymphocyte count to frailty and its usefulness as a prognostic biomarker in patients >65 years of age with acute coronary syndrome[J]. Am J Cardiol, 2020, 125(7): 1033 – 1038. doi: 10.1016/j.amjcard.2020.01.006
[21]	Liang YD, Liu Q, Du MH, et al. Urinary 8-oxo-7, 8-dihydro-guanosine as a potential biomarker of frailty for elderly patients with cardiovascular disease[J]. Free Radic Biol Med, 2020, 152: 248 – 254. doi: 10.1016/j.freeradbiomed.2020.03.011
[22]	Bernabeu-Wittel M, Gómez-Díaz R, González-Molina Á, et al. Oxidative stress, telomere shortening, and apoptosis associated to sarcopenia and frailty in patients with multimorbidity[J]. J Clin Med, 2020, 9(8): 2669. doi: 10.3390/jcm9082669
[23]	陈斯越, 汪慧菁. 从肠道菌群角度探讨氧化应激在衰弱发生中的作用[J]. 老年医学与保健, 2020, 26(4): 692 – 695. doi: 10.3969/j.issn.1008-8296.2020.04.049
[24]	Jones RM, Mercante JW, Neish AS. Reactive oxygen production induced by the gut microbiota: pharmacotherapeutic implications[J]. Curr Med Chem, 2012, 19(10): 1519 – 1529. doi: 10.2174/092986712799828283
[25]	Maggio M, De Vita F, Lauretani F, et al. IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty[J]. Nutrients, 2013, 5(10): 4184 – 4205. doi: 10.3390/nu5104184
[26]	Ticinesi A, Nouvenne A, Cerundolo N, et al. Gut microbiota, muscle mass and function in aging: a focus on physical frailty and sarcopenia[J]. Nutrients, 2019, 11(7): 1663. doi: 10.3390/nu11071663
[27]	胡倩. 衰弱综合征的围术期麻醉管理[J]. 重庆医学, 2021, 50(20): 3576 – 3580. doi: 10.3969/j.issn.1671-8348.2021.20.035
[28]	Jiang S, Kang L, Zhu ML, et al. A potential urinary biomarker to determine frailty status among older adults[J]. Arch Gerontol Geriatr, 2020, 88: 104038. doi: 10.1016/j.archger.2020.104038
[29]	Welstead M, Muniz-Terrera G, Russ TC, et al. Inflammation as a risk factor for the development of frailty in the Lothian birth cohort 1936[J]. Exp Gerontol, 2020, 139: 111055. doi: 10.1016/j.exger.2020.111055
[30]	Crimmins E, Vasunilashorn S, Kim JK, et al. Biomarkers related to aging in human populations[J]. Adv Clin Chem, 2008, 46: 161 – 216.
[31]	Semmarath W, Seesen M, Yodkeeree S, et al. The association between frailty indicators and blood-based biomarkers in early-old community dwellers of Thailand[J]. Int J Environ Res Public Health, 2019, 16(18): 3457. doi: 10.3390/ijerph16183457
[32]	Nascimento CMC, Zazzetta MS, Gomes GAO, et al. Higher levels of tumor necrosis factor β are associated with frailty in socially vulnerable community-dwelling older adults[J]. BMC Geriatr, 2018, 18(1): 268. doi: 10.1186/s12877-018-0961-6
[33]	Kochar BD, Cai W, Ananthakrishnan AN. Inflammatory bowel disease patients who respond to treatment with anti-tumor necrosis factor agents demonstrate improvement in pre-treatment frailty[J]. Dig Dis Sci, 2022, 67(2): 622 – 628. doi: 10.1007/s10620-021-06990-8
[34]	Yamamoto M, Adachi H, Enomoto M, et al. Lower albumin levels are associated with frailty measures, trace elements, and an inflammation marker in a cross-sectional study in Tanushimaru[J]. Environ Health Prev Med, 2021, 26(1): 25. doi: 10.1186/s12199-021-00946-0
[35]	Kim D, Won CW, Park Y. Association between erythrocyte levels of n-3 polyunsaturated fatty acids and risk of frailty in community-dwelling older adults: the Korean frailty and aging cohort study[J]. J Gerontol A Biol Sci Med Sci, 2021, 76(3): 499 – 504. doi: 10.1093/gerona/glaa042
[36]	Soh Y, Won CW. Association between frailty and vitamin B12 in the older Korean population[J]. Medicine (Baltimore), 2020, 99(43): e22327. doi: 10.1097/MD.0000000000022327
[37]	Kaimoto K, Yamashita M, Suzuki T, et al. Association of protein and magnesium intake with prevalence of prefrailty and frailty in community-dwelling older Japanese women[J]. J Nutr Sci Vitaminol (Tokyo), 2021, 67(1): 39 – 47. doi: 10.3177/jnsv.67.39
[38]	Wang ZD, Yao S, Shi GP, et al. Frailty index is associated with increased risk of elevated BNP in an elderly population: the Rugao longevity and ageing study[J]. Aging Clin Exp Res, 2020, 32(2): 305 – 311. doi: 10.1007/s40520-019-01189-4
[39]	李莹莹. 老年住院患者血N末端B型利钠肽原水平与衰弱的关系及临床应用研究[D]. 北京: 北京协和医学院, 2020.
[40]	Liu CK, Lyass A, Larson MG, et al. Biomarkers of oxidative stress are associated with frailty: the Framingham Offspring Study[J]. Age (Dordr), 2016, 38(1): 1. doi: 10.1007/s11357-015-9864-z
[41]	Lorenzi M, Lorenzi T, Marzetti E, et al. Association of frailty with the serine protease HtrA1 in older adults[J]. Exp Gerontol, 2016, 81: 8 – 12. doi: 10.1016/j.exger.2016.03.019
[42]	Liu ZY, Shen YY, Ji LJ, et al. Association between serum β2-microglobulin levels and frailty in an elderly Chinese population: results from RuLAS[J]. Clin Interv Aging, 2017, 12: 1725 – 1729. doi: 10.2147/CIA.S142507
[43]	Dalrymple LS, Katz R, Rifkin DE, et al. Kidney function and prevalent and incident frailty[J]. Clin J Am Soc Nephrol, 2013, 8(12): 2091 – 2099. doi: 10.2215/CJN.02870313
[44]	Lu WH, Giudici KV, Rolland Y, et al. Prospective associations between plasma amyloid-beta 42/40 and frailty in community-dwelling older adults[J]. J Prev Alzheimers Dis, 2021, 8(1): 41 – 47.
[45]	Lu WH, Giudici KV, Guyonnet S, et al. Associations of plasma neurofilament light chain and progranulin with frailty in older adults[J]. J Am Geriatr Soc, 2022, 70(4): 1236 – 1243. doi: 10.1111/jgs.17604