Abstract: In 2019 as a national key research program, the Development and Effectiveness Evaluation of an Innovative Health Management Model – Internet plus Medical Alliance-based Co-prevention and Co-management on Cardio-cerebrovascular Diseases was initiated in several regions including Shanghai and Guangzhou municipality and Xinjiang Uygur Autonomous Region. The ROCCIPI framework refers to a way of identifying and analyzing fundamental causes of problems in health policy through interrelated thinking patterns of seven elements: rule, opportunity, capacity, communication, interest, process and ideology. The framework could provide an evidence-based strategic approach to solve health policy problems. In this article, we try to identify and analyze the progress and problems in the implementation of the innovative health management at 21 comprehensive demonstration regions in China based on the ROCCIPI framework. Specific suggestions are also presented for promoting the comprehensive disease prevention and management project.