Trend and hotspots of research on highly pathogenic pathogens: visual analysis based on bibliometrics and bi-clustering
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摘要:
目的 为全面了解当前国际高致病性病原研究发展态势，为我国高致病性病原防控研究布局及生物安全提供科学参考。 方法 基于Web of Science数据库，以我国《人间传染的病原微生物名录》中列为危害程度为第一类的29种高致病性病原为研究对象，对1900 — 2022年有关29种高致病性病原相关论文进行主题检索。采用gCLUTO、bicomb等工具对论文数据进行多维尺度的可视化分析，总结研究态势、热点和聚类主题。 结果 共检索得到27840篇论文，其中，黄热病毒、埃博拉病毒、天花病毒相关论文分别有6970、6691、6459篇，是研究最多的前3个高致病性病原。2012 — 2022年高致病性病原研究热度上升，美国、英国、德国是高致病性病原领域的前3个研究国家；其中，美国在埃博拉病毒、黄热病毒、天花病毒、猴痘病毒等领域发文量远超其他国家。通过高频关键词和主题聚类分析，高致病性病原领域研究热点多聚焦在疫苗、药物研发方面。 结论 我国需及时关注国际高致病性病原领域研究动态，针对当前研究较少、尚未在国内流行以及频发、再发风险较高的高致病性病原需加强研究布局，提升新发和烈性传染病防控及国家生物安全的科技保障。 Abstract:Objective To examine status quo and development trends of research worldwide on highly pathogenic pathogens. Methods In this study, highly pathogenic pathogens refered to 29 pathogens classified as pathogens of first category in the List of Human Pathogenic Microorganisms released by National Health Commission on December 31, 2021. Research papers relevant to the 29 pathogens published worldwide from 1900 to 2022 were retrieved based on thematic search through Web of Science database and were analyzed visually and multi-perspectively using gCLUTO and bicomb and research themes, hotspots and clustering topics of the papers were summarized. Results Totally 27 840 papers were retrieved, of which, 6 970, 6 691, and 6 459 were relevant to the top three pathogens most frequently studied: yellow fever virus, Ebola virus, and variola virus. The number of research papers relevant to the 29 pathogens increased during 2012 – 2022. The first three countries with more authors submitted relevant research papers are United States, United Kingdom, and Germany; the authors from the United States submitted more research papers on Ebola virus, yellow fever virus, variola virus, and monkeypox virus compared to the authors from United Kingdom and Germany. The results of high-frequency keywords and thematic clustering analysis showed that investigations on the development of vaccine and drugs related to the highly pathogenic pathogens were research hotspots in those published papers. Conclusion Chinese scholars should pay attentions to international research on highly pathogenic pathogens for the prevention of the emerging and fulminating infectious diseases and biosafety. -
图 1 1900 — 2022年29种高致病性病原研究领域的整体论文数量情况
Figure 1. The number of research articles on 29 high pathogenic pathogens published worldwide during 1900 – 2022
图 2 1900 — 2022年29种高致病性病原相关研究领域随时间的变化
注：A: 1900 – 1930； B: 1931 – 1960；C: 1961 – 1990；D: 1991 – 2022
Figure 2. The visualization matrix for the number of research articles on 29 high pathogenic pathogens published worldwide per year during 1900 – 2022
图 3 不同国家在不同高致病性病原领域的研究现状
Figure 3. The visualization matrix for country-specific number of research articles on 29 high pathogenic pathogens published during 1900 – 2022
图 4 埃博拉病毒领域的双聚类分析可视化矩阵和可视化山丘图
注：数字代表不同的组。
Figure 4. The matrix visualization and mountain map visualization for bicluster analysis on research themes of all published studies relevant to Ebola virus during 1990 – 2022
图 5 黄热病毒领域的双聚类分析可视化矩阵和可视化山丘图
注：数字代表不同的组。
Figure 5. The matrix visualization and mountain map visualization for bicluster analysis on research themes of all published studies relevant to yellow fever virus during 1990 – 2022
图 6 天花病毒领域的双聚类分析可视化矩阵和可视化山丘图
注：数字代表不同的组。
Figure 6. The matrix visualization and mountain map visualization for bicluster analysis on research themes of all published studies relevant to variola virus during 1990 – 2022
表 1 高致病性病原研究领域的前10高频关键词（27840篇论文）
Table 1. The top 10 high-frequency keywords in 27 840 research articles on high pathogenic pathogens published worldwide during 1900 – 2022
序号 关键词 频次 序号 关键词 频次 1 vaccine 988 6 mosquito 255 2 aedes aegypti 455 7 public health 246 3 epidemiology 395 8 outbreak 198 4 vsaccination 387 9 ixodes ricinus 187 5 antiviral 328 10 surveillance 180 
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表 2 中国、美国在高致病性病原研究领域的前10高频关键词（12115篇论文）
Table 2. The top 10 high-frequency keywords in 12 115 research articles on high pathogenic pathogens submitted by authors from China and the United States during 1900 – 2022
中国 美国 序号 关键词 频次 序号 关键词 频次 1 vaccine 32 1 vaccine 434 2 glycoprotein 19 2 aedes aegypti 221 3 aedes aegypti 15 3 mosquito 151 4 antiviral 13 4 antiviral 148 5 epidemiology 10 5 vaccination 111 6 crystal structure 10 6 epidemiology 107 7 Infectious disease 9 7 pathogenesis 92 8 outbreak 8 8 public health 78 9 entry inhibitor 8 9 bioterrorism 76 10 ticks 8 10 surveillance 68
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[1] 尹建华, Baloch Z, 夏雪山. 中国30年来新发病毒性传染病与病毒溯源综述[J]. 昆明理工大学学报(自然科学版), 2021, 46(4): 86 – 93. [2] 关武祥, 陈新文. 新发和烈性传染病的防控与生物安全[J]. 中国科学院院刊, 2016, 31(4): 423 – 431. [3] 卢浪, 徐能武. 人类命运共同体视域下的全球生物安全治理 —— 现状分析、原因探究与路径选择[J]. 湘潭大学学报(哲学社会科学版), 2022, 46(2): 115 – 120. [4] Macpherson CNL. Human behaviour and the epidemiology of parasitic zoonoses[J]. International Journal for Parasitology, 2005, 35(11/12): 1319 – 1331. [5] 陈方, 张志强, 丁陈君, 等. 国际生物安全战略态势分析及对我国的建议[J]. 中国科学院院刊, 2020, 35(2): 204 – 211. [6] 中华人民共和国卫生部. 人间传染的病原微生物名录(卫科教发〔2006〕15号)[EB/OL]. (2006 – 01 – 11)[2021 – 09 – 10]. http://www.Nhc.gov.cn/wjw/gfxwj/201304/64601962954745c1929e814462d0746c.shtml. [7] 王亚丽, 周蕾, 任瑞琦, 等. “一带一路”国家黄热病输入我国的风险评估[J]. 疾病监测, 2021, 36(6): 534 – 538. [8] World Health Organization. Disease outbreak news; Yellow fever in East, West, and central Africa[EB/OL]. (2023-01-03)[2023-01-10].https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON431. [9] 马丽丽, 吴跃伟, 魏滨, 等. 知识图谱视角下埃博拉病毒研究态势分析[J]. 中国公共卫生, 2019, 35(1): 89 – 94. [10] 杜珊珊, 邓雪飞, 黄晓霞, 等. 马尔堡病毒病的流行特征及其临床表现与预防控制[J]. 疾病监测, 2022, 37(6): 832 – 838. [11] 邵楠, 曹玉玺, 王环宇. 拉沙热研究进展[J]. 微生物与感染, 2016, 11(6): 329 – 337. [12] 吴俣, 刘珏, 刘民, 等. 猴痘的流行病学特征及其科学防控[J]. 中华疾病控制杂志, 2022, 26(9): 996 – 999. [13] 马丽丽, 陈晓晖, 吴跃伟, 等. 依托大科学设施的生物安全国家实验室建设经验与启示[J]. 科技进步与对策, 2019, 36(2): 20 – 27. [14] Bowen MD, Peters CJ, Nichol ST. The phylogeny of New World (Tacaribe complex) arenaviruses[J]. Virology, 1996, 219(1): 285 – 290. doi: 10.1006/viro.1996.0248 [15] 段现蓉, 赵捧未. 基于共引与共词分析的国内移动商务核心知识与热点识别[J]. 情报科学, 2016, 34(12): 64 – 69. [16] 方丽, 崔雷. 利用双聚类算法探测学科前沿及知识基础 —— 以h指数研究领域为例[J]. 情报理论与实践, 2014, 37(11): 55 – 60. [17] Hensley LE, Geisbert TW. The contribution of the endothelium to the development of coagulation disorders that characterize Ebola hemorrhagic fever in primates[J]. Thrombosis and Haemostasis, 2005, 94(2): 254 – 261. [18] Weyer J, Grobbelaar A, Blumberg L. Ebola virus disease: history, epidemiology and outbreaks[J]. Current Infectious Disease Reports, 2015, 17(5): 21. doi: 10.1007/s11908-015-0480-y [19] Klitting R, Gould EA, Paupy C, et al. What does the future hold for yellow fever virus?(I)[J]. Genes, 2018, 9(6): 291. doi: 10.3390/genes9060291 [20] Rezza G. Vaccines against chikungunya, Zika and other emerging Aedes mosquito - borne viruses: unblocking existing bottlenecks[J]. Future Virology, 2016, 11(11): 723 – 730. doi: 10.2217/fvl-2016-0067 [21] Robinson-Dunn B. The microbiology laboratory's role in response to bioterrorism[J]. Archives of Pathology and Laboratory Medicine, 2002, 126(3): 291 – 294. doi: 10.5858/2002-126-0291-TMLSRI [22] Battin J. Pandemics: lessons from the past[J]. Bulletin de l'Académie Nationale de Médecine, 2020, 204(7): 737 – 740. [23] Sliva K, Schnierle B. From actually toxic to highly specific – novel drugs against poxviruses[J]. Virology Journal, 2007, 4: 8. doi: 10.1186/1743-422X-4-8 [24] Lusk B, Keeling AW, Lewenson SB. Using nursing history to inform decision - making: infectious diseases at the turn of the 20th century[J]. Nursing Outlook, 2016, 64(2): 170 – 178. doi: 10.1016/j.outlook.2015.11.011 [25] 戴长征, 毛闰铎. 从安全困境、发展安全到总体国家安全观 —— 当代国家安全理念的变迁与超越[J]. 吉林大学社会科学学报, 2022, 62(6): 29 – 44, 231 – 232. [26] 丁浩, 刘清, 齐江蕾, 等. 基于网络突发公共卫生事件早期谣言识别研究 —— 以新冠疫情谣言为例[J]. 情报科学, 2023, 41(4): 156 – 163. [27] 边晓慧, 徐童. 重大突发公共卫生事件下的公众情感演进分析: 基于新冠肺炎疫情的考察[J]. 数据分析与知识发现, 2022, 6(7): 128 – 140. [28] 张敬炟, 赵锐, 郭贺, 等. SARS以来我国突发公共卫生事件应对法律文本的政策工具量化分析[J]. 中国卫生事业管理, 2022, 39(7): 527 – 532, 555. -
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