Abstract: The intelligent platform for comprehensive management of tuberculosis in Shandong province (hereinafter referred to as the ‘intelligent platform’) is built with microservice architecture, and has technical features such as high performance, lightweight, concurrent programming model, standard library support, cross-platform, debugging and testing friendly, and integration with container technology. The construction of intelligent platforms relies on cloud architecture-related technologies to segment physical computing, storage, and network resources, supporting customers to use various terminals to obtain services from any location. The intelligent platform integrates advanced technologies such as information technology, artificial intelligence and big data analysis, which can strengthen the publicity and education of tuberculosis prevention and control knowledge, improve the detection of tuberculosis patients, improve the diagnostic efficiency, strengthen the overall management of tuberculosis patients during drug taking, and improve the efficiency of the daily work of tuberculosis prevention and control in the province. According to the statistics of patient management since the operation of the intelligent platform, the patient notification rate is 93.5%, the rate of taking medication on time is 77.4%, and the rate of regular medication use is 95.6%. The platform has great potential to improve the level of tuberculosis prevention and control, strengthen the management of medical resources and promote the intellectualization of the health system, which is of great significance for the effective control and prevention of tuberculosis.