Abstract: According to the geographical distribution feature of malaria epidemic in Guangzhou in recant ten years,taking species of mosquito vector、malaria incidence and topograghy as the indices, the malaria endemic area in Guangzhou could be divided into 4 stratification:northren mountainous region is meso-or hyper-endemic;hilly region is hypo-endimic;plain or basin region is sporadic-endemic;urban is non-endemic.Survellance and control met hods was mentioned in different stratification in this paper.