Abstract: To understand the risk factors of non-insulin dependent diabetes mellitus(NIDDM)of coastal population,a1:2 matched case-control study of 101 cases was conducted.The results of multi-variable conditional Logistic regression analysis of these factors showed that family history of diabetes,overw eight,hypertension were the risk factors of this population,their odds ratios(ORs) were 3.922,2.391 and 3.162 respectively;favor of vegetable diet was the protective factor,its OR was 0.445.The results of combined analysis of these factors showed that when overweight and unfavor of vegetable diet coexited,it showed the multiplicative model interaction;those who having family history of diabetes and over weight and unfavor of vegetable dietor those who had overweight and hypertension and unfavor of vegetable dietor those who had overweight and hypertension and unfavor of vegetable diet the key population for intervention of the disease.